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7:30am-6:30pm Registration Open

7:30-8:15 Technology Breakfast Workshop
Novel Clone Resources and Assay Technologies for Functional Studies
John Carrino, Ph.D., Vice President, Research and Development, Invitrogen Corporation

8:30 Chairperson's Remarks
Dr. Michael Hucka, Staff Scientist, California Institute of Technology

8:40 The Systems Biology Mark-up Language (SBML) Level 2
Dr. Michael Hucka

9:10 Tools for Large-Scale Distributed Simulations in Systems Biology
Dr. John Ambrosiano, Research Scientist, Computational Biosystems, Computer and Computational Sciences Division, Advanced Computing Laboratory, Los Alamos National Laboratory

9:40 Informatics for Systems Biology Knowledge Integration
Dr. Bret Peterson, Project Officer, National Center for Research Resources, National Institutes of Health

10:10 Refreshment Break in Exhibit Hall

11:10 Systems Biology from an Information Technology Perspective: Linking Diverse Biological Data Sources
Dr. Ronald Shymko, Head of Scientific Computing, Novo Nordisk A/S

11:40 Control Systems Analysis of Signaling Pathways
Dr. Herbert Sauro, Assistant Professor of Computational Biology, Keck Graduate Institute of Applied Life Sciences

12:20 Biological Complexity and Robustness
Dr. John Doyle, Professor of Control and Dynamical Systems, BioEngineering & Electrical Engineering, California Institute of Technology

1:00 Lunch in Exhibit Hall

2:30 Chairperson's Remarks
Dr. Len Pennacchio, Staff Scientist, Life Sciences Division, Lawrence Berkeley National Laboratory

2:40 Playing Practical Games with Bacteria and Viruses
Dr. Adam Arkin, Assistant Professor, Bioengineering, University of California, Berkeley; Assistant Investigator, Howard Hughes Medical Institute; Member, Biophysical Sciences Division, Lawrence Berkeley National Laboratory

3:10 Exploiting Vertebrate Sequence for Insights into Human Biology
Dr. Len Pennacchio

3:40 Statistical Analysis of T-Cell Gene Expression Time Courses
Dr. Adrienne James, Postdoctoral Research Scientist, Computational Biology and Chemistry Group, Novartis Research Institute

4:10 Refreshment Break in Exhibit Hall

4:50 Functional Implications of Alternative Designs for Genetic Switches and Signal Transduction Modules
Dr. Michael Savageau, Professor and Chair, Department of Microbiology and Immunology, University of Michigan Medical School

5:20 Genetic and Functional Approaches to Delineate Signal Transduction Pathways, Especially in the PI3'K and NFkB Pathways
Dr. Tak Mak, Professor, Department of Medical Biophysics, University of Toronto

7:30-8:15 Technology Breakfast Workshop
Enabling Protein Informatics:
Tools for Generating, Managing and Mining Research Data
Sponsored by Non-Linear Dynamics

8:30 Chairperson's Remarks
Dr. Bernhard O. Palsson, Co-Founder and Chairman, Genomatica; and Professor of Bioengineering and Adjunct Professor of Medicine, University of California, San Diego

8:40 The Silicon Cell and Network-Based Drug Design
Prof. J. L. Snoep, Department of Biochemistry, University of Stellenbosch

9:10 Discovery of Disease Markers Using a Systems Biology Platform
Dr. Stephen Naylor, Chief Technology Officer, Beyond Genomics, Inc.

9:40 In Silico Microbe Models and the Drug Discovery Process
Dr. Bernhard O. Palsson

10:10 Refreshment Break in Exhibit Hall

10:50 A Systems Biology Approach to Understanding Cellular Functions
Dr. Hiroaki Kitano, Project Director, ERATO Kitano Symbiotic Systems Project, Japan Science and Technology Corporation; and Senior Researcher, Sony Computer Science Laboratories, Inc.

11:20 eBiology to Improve Decision Making in Drug Discovery
Dr. Didier Scherrer, Senior Scientist, Entelos, Inc.

12:40 Lunch in the Exhibit Hall

2:10 Chairperson's Remarks

2:20 Applying the Entelos Metabolism PhysioLab to Pharmaceutical R&D
Dr. Xiaobin Zhang, Biosystems Engineer, Medical Informatics, Johnson & Johnson Pharmaceutical Research & Development, LLC

2:50 A Systems Biology Approach for Ab Initio Hepatotoxicity Based on Global Transcription Profiles
Dr. Xuding Dai, Senior Data Analyst, Merck & Co., Inc.

3:50 Refreshment Break

4:10 The Use of Well-Defined in Vitro Models and Gene Expression Profiling to Identify Novel Therapeutic Targets
Dr. Mary E. Gerritsen, Senior Director, Vascular Biology, Millennium Pharmaceuticals, Inc.

4:40 In Silico Approaches to Predicting Drug Metabolism, Toxicology, and Beyond
Dr. Sean Ekins, Associate Director, Concurrent Pharmaceuticals

5:10 From Gene Networks to Drug Targets
Dr. Jian Zhu, Senior Scientist, Novartis Institute of Biomedical Research, Novartis AG