1:30pm Registration

2:00-5:00 Pre-conference Tutorial A*
Introduction to Systems Biology: From Low-Level Analysis to "In Silico" Biology
Dr. Zoltan Szallasi, Assistant Professor, Children’s Hospital Informatics Program, Harvard Medical School

Pre-conference Tutorial B*
Aptamers: Creating the Next Generation in Therapeutics and Drug Discovery Tools
Dr. Charles Wilson, Vice President, Technology, Archemix Corp.

* Separate Registration Required

7:30am-6:30pm Registration Open

7:30-8:30am Light Continental Breakfast

8:30 Chairperson's Remarks
Dr. John N. Weinstein, Senior Investigator, Genomics & Bioinformatics Group, Laboratory of Molecular Pharmacology, CCR, National Cancer Institute

8:40 Computational Systems Biology of Peroxisome Biogenesis
Dr. Benno Schwikowski, Assistant Professor, Institute for Systems Biology

9:10 The Biomolecular Interaction Database: Curating Molecular Assembly Information Worldwide
Dr. Christopher W.V. Hogue, Scientist, Samuel Lunenfeld Research Institute, and Assistant Professor, Department of Biochemistry, University of Toronto

9:40 Computational Tools for Analyzing High-Throughput Mass Spectrometry of Microbial Proteins
Dr. William Cannon, Senior Research Scientist, Computational Biosciences, Pacific Northwest National Laboratory

10:10 Refreshment Break

10:30 Location Proteomics: Automated Interpretation of Fluorescence Microscope Images
Dr. Robert Murphy, Associate Professor, Biological Science/Biomedical Engineering, Carnegie Mellon University

11:00 Bioinformatics of Protein Kinases
Dr. Michael Gribskov, Senior Staff Scientist, Computational Molecular Biology, San Diego Supercomputer Center, University of California, San Diego

11:30 Using Signal Processing and Other Techniques to Generate Gene Network Hypotheses
Dr. Atul Butte

12:00-1:30 Lunch on your own

1:30 Chairperson's Remarks
Dr. Atul Butte, Assistant in Endocrinology and Informatics and Attending Physician, Children's Hospital, Boston, and Instructor in Pediatrics, Harvard Medical School

1:40 To Be Announced

2:10 Mapping Pathways from Genes to Brain Diseases with Applied Neuroinformatics
Dr. Floyd Bloom, Chairman of the Board, Neurome, Inc.

2:40 Practical Tools and Resources for Analysis, Biological Interpretation, and Integration of Microarray Data
Dr. John N. Weinstein

3:10-3:30 Refreshment Break

3:30 The Visualization of Statistical Significance and Its Application to Microarray Data
Dr. David Finkelstein, Data Analysis Scientist, Affymetrix, Inc.

4:00 New Approaches to Software Interoperability: the LSid Reference Model
Mr. Tim Clark, Vice President, Informatics, Millennium Pharmaceuticals, Inc.

4:30-5:00 Large Scale Gene Expression Data Management, Integration and Analysis
Dr. Victor M. Markowitz, Chief Information Officer and Senior Vice President, Data Management Systems, Gene Logic Inc.

7:30am-5:00pm Registration Open

8:15am Light Continental Breakfast

8:30 Chairperson's Remarks
Dr. Jeffrey R. Sachs, Senior Research Fellow, Applied Computer Science and Mathematics, Merck Research Laboratories, Merck & Co., Inc.

8:40 Rich Subtext of Gene Expression Deciphered through the Lens of Gene Ontology
Dr. Philip Xiang, Director, Bioinformatics, Roche Molecular Systems, Inc.

9:10 Direct Application of Biological Networks to Pharmaceutical Development
Dr. Jeffrey R. Sachs

9:40 The Druggable Genome: Analysis of Alternative Splicing in Pharmaceutically Relevant Protein Families
Dr. Brian Moldover, U.S. Head, Bioinformatics, Aventis Pharmaceuticals

10:10 Refreshment Break

10:30 Gene Expression Profiling and Cancer Diagnostics
Dr. Yixin Wang, Principal Scientist, Advanced Diagnostic Systems, Molecular Diagnostics, Johnson & Johnson Company

11:00 Understanding Transcriptional Regulation in Disease: The Application of Bioinformatics and Molecular Approaches to the Study of Nuclear Receptors
Mr. Mark Downey-Jones, Local Head of Bioinformatics, Respiratory and Inflammation Research Area, AstraZeneca

11:30 Computing Platforms for Transcriptional Profiling of Minor Messages
Dr. Jeff Augen, President, TurboWorx Inc.

12:00-1:30 Technology Workshop
Annotation of the Human Genome by High-Throughput Sequence
Analysis of Naturally Occurring Proteins
Presented by Dr. Jonathan Sheldon, Confirmant Ltd.

1:30 Chairperson's Remarks
Dr. Terry Gaasterland, Assistant Professor, Computational Genomics, Rockefeller University

1:40 Genomewide Identification of Small Molecule Binding Sites on Microbial Proteins
Dr. Lee Makowski, Director, Biosciences Division, Argonne National Laboratory

2:10 From Networks of Heterogeneous Associations to Drug Discovery Decision Support
Dr. Otto Ritter, Associate Director, Bioinformatics, AstraZeneca R&D Boston

2:40 From Hits and Genes to Drugs and Hybrids: Towards Integrated Life Sciences Data Mining
Dr. David R. Argentar, Senior Specialist, Information & Computing Technologies, DuPont

3:10 Informatics Methods for Correlating Molecular Structure with Genomic Data
Dr. Paul E. Blower, Chief Scientific Officer, LeadScope Inc.

3:40 Refreshment Break

4:10 The Alpha Project and the Dream of a Predictive Biology
Dr. Roger Brent, President and Research Director, The Molecular Sciences Institute; and Adjunct Professor, University of California, San Francisco

4:50-6:30 Opening Reception in Exhibit Hall