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Wednesday, June 18

7:30-8:15 Continental Breakfast/Technology Workshop: Novel Clone Resources and Assay Technologies for Functional Studies
Presented by John Carrino, Ph.D., Vice President, Research and Development, Invitrogen Corporation
Sponsored by Invitrogen

8:30-8:40 Chairperson's Remarks
Dr. Daniel W. Chan, Professor of Pathology, Oncology, Radiology & Urology, Director of Clinical Chemistry Division, Department of Pathology, and Director of Biomarker Discovery Center, Johns Hopkins Medical Institutions

8:40-9:10 Differential Proteomics in Disease-Specific Biomarker Discovery
Dr. Stephen Naylor, Chief Technology Officer, Beyond Genomics, Inc.

9:10-9:40 Mass Spectrometry: A Direct Route to Diagnostic Marker Discovery in Rheumatoid Arthritis
Dr. Brad Guild, Director of Biomarker Discovery Proteomics, Millennium Pharmaceuticals

9:40-10:10 Serum Proteomic Pattern Diagnostics Using SELDI-MS and Bioinformatics
Dr. Daniel Chan

10:10-11:10 Coffee Break in the Exhibit Hall

11:10-11:40 High-Throughput, Quantitative Detection of Disease Markers in Serum Using Antibody Microarrays
Dr. Achim Brinker, Principle Investigator, Genomics Institute of the Novartis Research Foundation

11:40-12:10 Use of Protein Profiling Chips for Biomarker Discovery to Guide Medical and Drug Development Decision Making
Dr. Stephen Kingsmore, Chief Operating Officer, Molecular Staging Inc.
Proteomics in Drug Development

12:20-1:00 Biological Complexity and Robustness
Dr. John Doyle, Professor of Control and Dynamical Systems, BioEngineering & Electrical Engineering, California Institute of Technology

1:00-2:30 Lunch in the Exhibit Hall

2:30-2:40 Chairperson's Remarks

2:40-3:10 Development and Application of Proteomics Methods in Discovery of Toxicity Biomarkers
Dr. Madhu S. Mondal, Senior Scientist, Drug Safety Evaluation, Pfizer Inc.

3:10-3:40 Correlation of Protein Structural and Functional Data in the Identification of Novel Pharmaceutical Agents: Small Molecule Proteomimetics
Dr. Tom Gadek, Senior Scientist, Department of Bioorganic Chemistry, Genentech, Inc.

3:40-4:10 Structure-Based Drug Discovery for Protein Kinase Targets
Dr. Stephen K. Burley, Chief Scientific Officer and Senior Vice-President Research, Structural GenomiX, Inc.

4:10-4:50 Ice Cream Refreshment Break in the Exhibit Hall

4:50-5:20 Identification of Tumor Immunotherapy Targets from Human Lung and Colon Using Advanced Proteomics
Dr. Clarissa Desjardins, Executive Vice-President, Corporate Development, Caprion Pharmaceuticals Inc.

5:20-5:50 Phosphorylation in Proteomics
Dr. Jennifer Caldwell Busby, Research Scientist, Analytical Mass Spectrometry, MDS Proteomics

5:50-6:20 Production of Therapeutic Proteins with Humanlike Glycosylation
Dr. Tillman Gerngross, Chief Scientific Officer, GlycoFi Inc.

7:30-8:15 Continental Breakfast/Technology Workshop

Enabling Protein Informatics: Tools for Generating, Managing and Mining Research Data

Sponsored by Nonlinear

8:30-8:40 Chairperson's Remarks

8:40-9:10 Proteome Analysis of p53-Dependent Neuronal Cell Death
Dr. Ming Zhou, Senior Scientist, Mass Spectrometry Center, Analytical Chemistry Laboratory, SAIC-Frederick, Inc., National Cancer Institute

9:10-9:40 Activity-Based Protein Profiling: Chemical Approaches for Functional Proteomics
Dr. Benjamin F. Cravatt, Departments of Chemistry and Cell Biology, The Scripps Research Institute

9:40-10:10 Proteomics in Aging
Dr. Fred Regnier, Professor of Chemistry, Purdue University

10:10-10:50 Coffee Break in the Exhibit Hall

10:50-11:20 Integration and Standardization: Driving Forces in Protein Informatics
Dr. Rolf Apweiler, Head of Sequence Database Group, EMBL Outstation, European Bioinformatics Institute

11:20-11:50 NHLBI Proteomics Initiative to Develop and Apply Innovative Proteomics Technologies
Dr. Susan Old, Leader, Bioengineering and Genomics Applications Group, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute

12:00-12:40 Genomics as the Foundation for the Discovery of New Therapeutic Products: From Theory to Practice
Dr. Vivian Albert, Vice President, Preclinical R & D, Human Genome Sciences, Inc.

12:40-2:10 Lunch in the Exhibit Hall — Last Chance for Viewing Exhibits and Posters

Protein Profiling Technologies

2:10-2:20 Chairperson's Remarks
Dr. David Goodlett, Director, Proteomics, Institute for Systems Biology

2:20-2:50 A Review of the Many Uses of Stable Isotope Labeling in Discovery-Based Proteomics
Dr. David Goodlett

2:50-3:20 Amino Acid-Specific Mass Tagging for Proteomics
Dr. Xian Chen, Technical Staff Member and Professor, Bioscience Division, Los Alamos National Laboratory

3:20-3:50 High-Performance Multidimensional Chromatography MALDI QFT-ICR MS for "Bottom Up" Proteomics
Dr. Ansgar Brock, Group Leader, Protein Sciences, Genomics Institute of the Novartis Research Foundation

3:50-4:10 Refreshment Break

4:10-4:40 Target-Assisted Iterative Screening (TAIS): A Novel Method for Mapping Protein Interaction Networks
Dr. Alexei Kurakin, Staff Scientist, Buck Institute for Research in Aging

4:40-5:10 Interaction Analyses Using Whole Proteome Microarrays
Dr. Barry Schweitzer, Director, R&D, Protometrix, Inc.

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