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[编者的话] 研究人员在今年5月26日出版的《柳叶刀》杂志上发表研究的报告中介绍了一例年轻男性患儿体内细菌耐药性的发展过程,该患儿出生后不久由于呼吸问题给与呼吸机治疗。最初,该患儿的感染症状对阿莫西林治疗较为敏感,阿莫西林是一种青霉素类抗生素。但是在经过几天的治疗之后,患儿的血液中开始出现对青霉素耐药的金黄色葡萄球菌。这项研究从一个侧面揭示了生物进化中一个重要的动力和现象,而这目前也是生物信息学研究的重点。
Dutch researchers report the
case of a neonate who had never been exposed to methicillin-resistant
Staphylococcus aureus. However, after antibiotic treatment, the neonate
was found to be positive for a novel isolate of the bug. The mecA
antibiotic-resistance gene was apparently transferred in vivo from one
staph strain to another. Reference: Wielders, C., Vriens, M., Brisse, S. et al. 2001. Evidence for in-vivo transfer of mecA DNA between strains of Staphylococcus aureus. Lancet 357(9269). |
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1999-2005 中国科学院上海生命科学研究院生物信息中心 |