In silico gene mapping

[编者的话]

研究者建立了一个小鼠SNP的数据库并发展了一种计算机模型来预测调控小鼠表型特征的染色体区段。首先，他们输入小鼠的表型数据，然后，他们分析了表型和基因型的信息，通过计算来查明调控特异特征的染色体位点。

Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months down to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.

想要了解更多，请见8 June 2001 - Science