Genomics to fluxomics and physiomics — pathway engineering

[abstract]

Developments in microanalytical methods are enabling quantitative measurement of multiple metabolic fluxes and, in conjunction with transcript and proteomic profiling, are revolutionizing the ability of researchers to manipulate metabolism through pathway engineering in a variety of species. We review recent literature on the advances in genomics, proteomics, fluxomics and computational modeling focused on metabolic pathway engineering applications.

Karl Sanford*, Phillipe Soucaille, Gregg Whited and Gopal Chotani

Genencor International, Inc., 925 Page Mill Road, Palo Alto,

California 94304, USA