关于人类基因组数据和预测信息的可视化技术

[编者的话]

文章原名为：Visualizing the genome techniques for presenting human genome data and annotations这是文章的原稿。下面是文章的摘要。

Background

In order to take full advantage of the newly available public human genome sequence

data and associated annotations, biologists require visualization tools ("genome

browsers") that can accommodate the high frequency of alternative splicing in human

genes and other complexities.

Results

In this article, we describe visualization techniques for presenting human genomic

sequence data and annotations in an interactive, graphical format. These techniques

include: one-dimensional, semantic zooming to show sequence data alongside gene

structures; color-coding exons to indicate frame of translation; adjustable, moveable

tiers to permit easier inspection of a genomic scene; and display of protein

annotations alongside gene structures to show how alternative splicing impacts

protein structure and function. These techniques are illustrated using examples from

two genome browser applications: the Neomorphic GeneViewer annotation tool and

ProtAnnot, a prototype viewer which shows protein annotations in the context of

genomic sequence.

Conclusion

By presenting techniques for visualizing genomic data, we hope to provide interested

software developers with a guide to what features are most likely to meet the needs of

biologists as they seek to make sense of the rapidly expanding body of public

genomic data and annotations.

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