Structural proteomics: the potential of high-throughput structure determination

[编者的话]

本文探讨了结构蛋白质组学在新药发现工作中所能起到的作用以及两者相结合所能带来的巨大突破。

The pharmaceutical industry has embraced genomics as a means to identify new biological targets for target-based drug discovery approaches. Now, genomics is driving a substantial effort in protein structure determination and structure prediction. These structures will provide the opportunity to undertake structure-guided drug discovery programs in the search for new classes of broad-spectrum antibiotics. In addition, these structures could provide structure-based criteria to prioritize certain targets for focused drug discovery programs.

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