Circadian clock and microarrays: mammalian genome gets rhythm

[编者的话]

利用芯片技术研究生物钟现象。

Circadian (daily) rhythms are found in most living organisms from cyanobacteria to mammals. They are generated by an internal ‘clock’ that is reset by external time cues and that regulates a variety of physiological functions through downstream target genes. Analysis of the mammalian transcriptome using DNA microarrays is now identifying hundreds of tissue-specific clock-controlled genes, which regulate an impressive diversity of biological processes.

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