From genetics and genomics to drug discovery: yeast rises to the challenge

[编者的话]

下文的思路和方法都很有意思。是一篇值得阅读的好文章。

To identify small-molecule inhibitors of human proteins, a rapid and high-throughput yeast methodology has been developed. Highly sensitive liquid growth assays report the interference of yeast growth caused by the expression of a heterologous protein, and the specificity of the phenotype is validated using known and novel schemas. The development of these high-throughput techniques in yeast validates this organism as an effective paradigm for drug discovery.

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