Inferences from whole-genome sequences of bacterial pathogens

[编者的话]

关于致病基因组研究的综述。文章介绍了比较基因组，基因芯片等方法在这类研究中的应用。

Genomic sequencing of bacterial pathogens has recently moved from the study of distantly related organisms to withinspecies comparisons of multiple strains. Strains often differ in their ability to cause disease, and comparative genomics is uncovering novel virulence determinants, hidden aspects of pathogenesis, and new targets for vaccine development. DNA microarrays and other gene-survey techniques are being used to quantify variability in gene content within bacterial populations, and to reveal the strain-specific basis for diversity and severity of pathology.

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