The presence and integrity of AF is fundamental for the normal development of the human fetus during pregnancy. Its production rate changes throughout pregnancy and is mainly related to the functions of the different fetal, placental, and amniotic compartments. Monitoring the proteomic content in AF can be used to evaluate premature rupture of fetal membranes (PROM) and to develop biomarkers for early detection of amniotic infection or inflammation.
Explorative Study of the Protein Composition of Amniotic Fluid by Liquid Chromatography Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
