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Cerebrospinal fluid
The cerebrospinal fluid (CSF) circulates within the CNS where it plays an essential physiological role in homeostasis of neuronal cells. This biological fluid has an important protein diversity that results from both filtration of serum through the blood-brain barrier and production/secretion of neuronal peptides and proteins. Changes in CSF composition depend on blood proteome, CSF circulation alterations, as well as physiological or pathological brain status. Hence, CSF proteomic analysis gives a unique opportunity to detect and describe biomarkers in neurological affections. Few CSF proteomic studies have been performed in comparison to those on blood.

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Papers about Cerebrospinal fluid:
PaperTitlePlatformBody Fluid
14998169 Proteomic Analysis of Human Ventricular Cerebrospinal Fluid from Neurologically Normal, Elderly Subjects Using Two-Dimensional LC-MS/MS 2-D LC-MS/MS Cerebrospinal fluid
15582749 Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid LC-MS/MS Cerebrospinal fluid
15952730 Evaluation of Protein Depletion Methods for the Analysis of Total-,Phospho- and Glycoproteins in Lumbar Cerebrospinal Fluid 2D gels,nanoLC-MS/MS Cerebrospinal fluid
17022648 Identification of Glycoproteins in Human Cerebrospinal Fluid with a Complementary Proteomic Approach 2D LC-MS/MS Cerebrospinal fluid
17853512 Differential protein expression in male and female human lumbar cerebrospinal fluid using iTRAQ reagents after abundant protein depletion LC-MS/MS Cerebrospinal fluid
18052119 Integrated Analysis of the Cerebrospinal Fluid Peptidome and Proteome LC-MS/MS Cerebrospinal fluid

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