葛兰素史克(中国)投资有限公司

GlaxoSmithKline (China) Investment CO., LTD.

The global R&D centres have over 16,000 scientists and technicians in many countries. To further promote the globalization of R&D, GlaxoSmithKline (GSK) China R&D Center was launched in June 2007. GSK R&D China will focus on research into neurodegeneration with the objective of discovering new medicines for such severe disorders as multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. GSK R&D China will grow to a global R&D center with more than 1,000 scientists and technicians. Research in this center will be science-driven, with development of novel therapeutics through innovation and latest technologies in biology and chemistry. The center will eventually direct the global discovery and development activities within its therapeutic area, from drug-target identification to late-stage clinical studies, while collaborating with research institutions in China and other countries. GSK R&D China will grow in the next decade to become one of the major GSK R&D centers.

联系人：HR
EMAIL：quy82098@gsk.com
网站：www.gsk.com 
 
 
   
资深科学家和科学家
 
工作地点： 上海 　
招聘人数： 不限
EMAIL：quy82098@gsk.com

职位职责：
Antibody Group
PhD leavel scientists participate in the design and execute panning and screening strategies of various phage display libraries. Perform assays that will enable the characterization and selection of desirable phage-derived antibodies against inflammation and oncology targets. Contact to : lixin.l.li@gsk.com。

Informatics Group
PhD level scientists in computational biology/bioinformatics, computational chemistry/cheminformatics, or statistics with at least 2 years relevant experience. Expertise in the application of statistical, data mining, visualization, pattern recognition and mathematical modeling methods and tools to analyze complex biological or chemical data sets. The ability to work well in an interdisciplinary team and present complex scientific topics are essential. Excellent communication and influencing skills. You will be highly numerate, thoroughly versed in computational literature and possess good problem solving skills. Knowledge of scripting and programming languages is a plus. Knowledge of neurodegenerative diseases or CNS is desired.

Neurodegenerative diseases group
We are looking for scientists who have experience in one of following areas: Neurodegenerative disorders such as Alzheimer’s or Parkinson’s. Familiar with at least two of the following biological technologies, e.g. Immunology, neuroscience, histomorphology, cell culture, experimental animal handling. Studying animal behavior e.g. cognition, transgenics as well as in vivo pharmacology, or developing animal models (e.g Parkinson’s or Alzheimer’s) or imaging (e.g. PET). Signaling transduction or studying enzymes particularly in kinases and protease or GPCRs.

Neuroinflammation group:
We are looking for individuals with working experience and knowledge in neuroscience and/or immunology preferable with extensive experience in neuroprotection or inflammtion. Those with experiment in animal models of multiple sclerosis such as EAE are strongly encouraged to apply. Master degree in science and above, with at least two year research experience is required.

Neuropathology group:
We are looking for individuals with working experience and knowledge in histology, pathology, immunohistochemisty, and/or electron microscopy, in the fields of neurodegenerative diseases. Bachelar degree in science and above, with at least two year research experience preferred.

Drug Metabolism and Pharmacokinetics (DMPK)
Requirements:
PhD/MS in a chemical, biological or equivalent pharmaceutical science based discipline. Strong organization, data management, and communication skills. Ability to work effectively in a team environment. Possess relevant technical expertise and lab skills, and troubleshoots problems in the execution of experimental/technical processes with minimal supervision. Experience in DMPK and an understanding of the drug discovery/development process is a plus. Contact to: Ji.Y.Zhang@gsk.com

Manager/Principal Scientist:
We are currently seeking highly self-motivated and talented cell biologist to join our mammalian cell culture group. Individuals will work closely with other members of our medicinal chemistry, biology and DMPK departments to identify monoclonal antibodies for the treatment of various CNS disorders.

Requirements: a Ph.D. degree in cell biology or life sciences related fields; experience in mammalian expression or cell culture in the pharmaceutical industry is a plus; ability to work independently; excellent organizational, communication (oral & written) and problem-solving abilities; hands-on experience in cell line banking, mammalian cell culture and gene expression;

Techniques; knowledge of automation and high throughput screening applicable to mammalian cell culture and/or cell line creation; excellent team player, capable of setting priorities and coordinating research plans in agreement with team and department established goals, priorities and timelines. Contact to: chichang.l.lee@gsk.com

   
Scientists
 
工作地点： 上海 　
招聘人数： multiple
联系人：HR
EMAIL：gang.z.an@gsk.com

职位职责：

Protein Biochemistry:

We are seeking PhD or MS Scientists/Senior Scientists with at least 3 years of research experience in biochemistry or other biological sciences. The scientist will purify and characterize various proteins from small to large scales to support therapeutic protein/antibody drug discovery for neurodegenerative diseases. The candidate should be proficient and have extensive hands on experience in protein purification and characterization, familiar with Akta FPLC system and characterization process such as Mass Spec, protease fragmentation et al. The candidate should have excellent written and verbal communication skills and be able to work in a team environment. Experience on protein engineering and expression will be helpful. Working experience in a biotechnology or pharmaceutical environment would be an advantage.

Fermentation:

We are seeking a PhD or MS Scientist/Senior Scientist in cell biology, biochemistry or other biological sciences with 3-5 years of prior experience in fermentation process and method development. The candidate should have extensive hands on experience on operating small to mid-scale fermentor or wave bag cell culture system. Ability to develop and improve fermentation strategy as well as implement novel processes. The candidate should have very strong working knowledge of microbial, insect and mammalian fermentation processes, and related processing equipment and systems. Extensive experience in media optimization is also desired. Demonstrated experiences are required in all aspects of cell culture including proper handling, maintenance and storage of E. coli, baculovirus and mammalian cultures. Prior experience with protein biochemistry will be helpful.

Protein expression

We are seeking a PhD or MS Scientist/Senior Scientist with 3-5 years of experience in molecular biology, biochemistry or other biological sciences. The scientist will be responsible for baculovirus generation, and protein expression. Experience in bacteria and mammalian expression systems are also desired. The candidate should have extensive hands on experience in generating baculovirus, and optimizing protein expression in different cell systems
The successful candidate is expected to have excellent record-keeping and communication skills and be able to work in a team environment.