China Novartis Institutes for BioMedical Research Co.,Ltd
A fully integrated research and development center, Novartis provides healthcare solutions that address the evolving needs of patients and societies. Novartis is a global healthcare leader, and has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicine brought to life by diverse, talented, performance driven people. All of which makes us one of the most rewarding employers in our field.
网站：http://www.novartis.com/careers/job-search/brassring/index.shtml (click “search openings” -> key in key word “CNIBR”)
公司地址：上海市浦东新区张江高科技园区哈雷路898弄8号楼
邮政编码：201203
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Research Scientist
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
China Novartis Institutes for Biomedical Research Co. Ltd (CNIBR) is currently seeking to fill a research scientist position in the High Throughput Biology Lab to develop innovative high throughput cell-based assays and biochemical assays to support the drug discovery effort at CNIBR. The main responsibility of the candidate is to establish and maintain a panel of tumor cell lines and to use this panel to screen for novel anti-tumor agents. Another responsibility is to help develop and evaluate novel cell-based HTS assays for various oncology targets.
Keyword: CNIBR 46214BR
Minimum requirements
The successful candidate should have a Ph.D. degree in cell biology, biochemistry, or related field with good hands on molecular biology experiences. Experience in HTS assay development in a drug discovery environment is a plus. Excellent English and communication skills are required.
Research Investigator
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
We are looking for an experienced, energetic and motivated scientist to join Biology team in China Novartis Institute for BioMedical Research in Shanghai. As Research Investigator, you must be passionate about drug discovery and development by engaging in Epigenetics and DNA methylation studies. You will have multiple roles in all aspects of TG/Knockout studies and phenotype analysis. You will conduct in vivo and in vitro studies, generate and analyze scientific data, and take leading roles in scientific directions of projects. You will also responsible for writing scientific papers, project reports, and research plans. Ability to working effectively with members of other teams is a plus. Excellent writing and oral communication skills are needed. You must be able to perform in a fast-paced, highly dynamic team-oriented environment.
Keyword: CNIBR, Shanghai, China
Minimum requirements
You are expected to have PhD degree in an appropriate biological discipline, such as Mouse Genetics, biological sciences, animal sciences, pharmaceutical sciences. A minimum of 8 year experience in biology, mouse-genetics, and TG/KO technology related laboratory is required. You will have demonstrated experience in mouse genetics, TG/KO technologies, and phenotype analyses. Competences in directing and managing research projects and junior associates, and working with scientists across various disciplines are a must. The ideal candidate should be team player, detail-oriented, and strive for scientific excellence. An understanding of scientific principles and experimental designs in pharmaceutical setting is important.
Post Doc Researcher - Chemistry
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
China Novartis Institutes for Biomedical Research Co. Ltd (CNIBR) in Shanghai is currently seeking to fill two 3-year term postdoctoral positions in the Chemistry department. CNIBR offers a dynamic and stimulating research environment which involves multidisciplinary interactions. The postdoctoral researchers will also interact with the global Novartis postdoctoral program. We provide a highly competitive benefit and compensation package for the positions.
Computer Aided Drug Design:
Your responsibility and focus will be on new and challenging innovations in the areas of computational enzyme structure and the understanding of enzyme binding, catalysis, and selectivity in the context of simulations. Possible relevant research experience would include computational enzyme design, applying computational methods (e.g. docking, homology modeling, conformational analysis, molecular dynamics) to the prediction of enzyme structures, binding, catalysis, and selectivity. Knowledge about QM/MM is an essential. Expertise in scientific programming and scripting is a plus. The qualified candidate must understand and have hands-on experience for one or two of the molecular modeling software (Schrödinger, Accelrys, SYBYL, etc.) and online databases (BLAST, BRENDA, RCSB PDB, ExPASy, etc.).
Metabolomics:
Metabonomics study is to profile the complete metabolite levels of cells, tissues and/or a whole organism and their changes as response to a disease (or disease status) or an drug (dosing levels), and eventually to identify disease or drug related differences in one or more of the numerous endogenous metabolites. Combined metabonomic, proteomic and genomic studies (-omics) can lead to accelerated development of mechanistic hypotheses for a disease, and improved understanding of clinical responses to a drug (e.g., efficacy and toxicity) from the level of molecular pathways and regulatory networks. The knowledge acquired from the omics has been integrated into systems biology research; and the omics approaches are being adopted in drug discovery process.
The successful candidate will be involved in a research program aimed at (1) building up an analytical platform for metabolic profiling, and (2) utilizing integrated omics (i.e., genomics, proteomics and metabolomics) approaches to characterize cancer cell lines and cancer stem cells (CSC) to advance our understanding of the relevance of cancer cell metabolism changes associated with cellular proliferation and tumor progression, thus to gain insights into the disease mechanism, and potentially to identify metabolite markers. The researcher will have opportunities of collaborating with internal and external biological and chemical scientists in many aspects.
Keyword: CNIBR
Minimum requirements
Computer Aided Drug Design：
Candidates for the position should have a PhD in chemistry, biology, computational science or interdisciplinary fields and have an academic record of scientific excellence, a flair for independent research and a strong interest in cross functional approaches and collaboration. Excellent English and communication skills are required.
Metabolomics：
The successful candidate should have a Ph.D. degree in biochemistry, chemistry or related field with good biological mass spectrometry experiences in proteomics and/or metabolomics fields. Excellent English and communication skills are required.
Stem Cell Associate
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
We are inviting self motivated scientists to join our stem cell program at CNIBR to focus on stem cell applications to our drug discovery and development efforts. The successful candidates will participate in the development of stem cell (ES cell, iPS cell, and cancer stem cell) based assays for drug target identification and validation as well as compound screen . He will be responsible for cell line generation, characterization and maintenance, differentiation of stem cell to various cell fates, and cell based assay development.
Minimum requirements
Strong background and technical skills in cell biology and molecular biology are required. Prior hands-on experience with human and rodent ES cell culture, induced pluripotent stem cell generation and characterization, or human hepatocyte differentiation/liver regeneration will be preferable. Expertise in small animal surgery is a plus. Good personal and communication skills in a team environment is essential.
Research Associate
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
We are looking for an energetic, motivated scientist to join the epigenetics team at NIBR to support drug discovery research in the epigenetics areas. A person in this role must be enthusiastic to contribute and share responsibilities with team members for biochemical and cell-based assay development. Experience with biochemical and cell based methods (protein purification, RNAi, tissue culture, cell growth/proliferation assays, western blot, immunoprecipitation, CHIP analysis) are required. Prior experience with small molecules handling and HTRF, DELFIA, ELISA assays are desired. Good understanding of enzymology is a plus.
Minimum requirements
A BS/MS life science degree and 1+ years of drug discovery experience, or a PhD degree in Biological Science with proven record of accomplishment are necessary. The candidate must have good organization and communication skills to work in a collaborative team environment. Excellent writing and presentation skills, with good multi-tasking ability are needed. Under the supervision of a senior scientist, you are expected to work independently to execute, interpret and troubleshoot experiments. Competences in maintaining lab notebooks and computer files are also required.
Research Associates/Technicians
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
We are recruiting enthusiastic associates to join JRL between Novartis R&D Center and Fudan University. You must be highly motivated, self-driven, and dedicated to discovery and development of therapeutic drugs. Advanced skills in laboratory and hand-on experience in experimental design, trouble-shooting and data analysis are required. Candidate must be able to communicate efficiently in both Chinese and English. Excellent interpersonal skills and team-work spirit are needed. Previous working experience in a team setting is a plus. Excellent communication skills in writing and oral presentation are required.
Minimum requirements
You are expected to have a Bachelor or a Master Degree in one of the following arrears: Molecular/Cellular Biology, Biochemistry, Medicine, Pharmacology or Animal Sciences. A minimum of 2 year experience in laboratory research is required. You need to have proven competences in standard techniques, including DNA/RNA/Protein manipulations, PCR analysis, cell culture and transfections, expression analysis, and computer skills. Candidates with hand-on experience working with small animals and stem cells are strongly encouraged to apply. Ideally, you will possess skills in creativity, problem-solving, logic thinking and team-work.
Research Investigators I or II/Assistant or Associate Professors
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
China Novartis Institutes for BioMedical Research Co., Ltd. (CNIBR) and Fudan University Institute of Biomedical Sciences (IBS), have established a Joint Research Laboratory (JRL). We are aiming to identify novel cancer targets and biomarkers for discovery and development of therapeutic drugs. Currently, there are multiple positions open at all levels.
We are looking for experienced, innovative, and highly motivated individuals to lead a team of scientists in cancer-related studies. As team leaders, you must be passionate about discovery and development of anti-cancer drugs for the benefits of human being. You will have multiple roles in all aspects of cancer-related research. You will lead in vitro and in vivo studies under the guidance of Senior Research Investigator/Professor, provide guidance for junior scientists, and ensure the smooth operation of multiple projects. You will also assist in data collection, organization and presentations. Excellent writing and oral communication skills are required. Strong leadership skills are necessary. In addition, abilities to present scientific results, write project reports, and publish papers in peer-reviewed journals are essential. You must be able to perform in a fast-paced, highly dynamic team-oriented environment.
Minimum requirements
You are expected to have Ph.D and/or M.D. in an appropriate biological disciplines, such as biological sciences, animal sciences, biochemistry, physiology, or pharmaceutical sciences. Additionally, experience of post-doc training and leading a research team is required. You need to have at least 5 year experience in biology or pharmacology related research. You will have demonstrated ability to utilize diverse resources for projects, to analyze, interpretate and present data, and to set up new directions for the team. Passion for scientific research and ability to motivate team members are also important.
Research Scientists /Post-doc Fellows
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
We are also recruiting Research Scientists/post-doctoral fellows for the JRL. The ideal candidates will participate in team efforts to discover novel targets for the understanding and treatment of cancers. Key responsibilities include investigation of cellular and molecular mechanisms of cancer formation, and their underlying genetics and signal transduction pathways. The scientist will perform hand-on research activities, and supervise activities of research associates daily. Ability to design, perform, and analyze experimental results is crucial. . The ideal candidates will have demonstrated capacity in scientific research and publications.
Minimum requirements
The position requires PhD and/or MD degree in relevant fields, such as Biology Sciences, Animal Sciences, Biochemistry, and Pharmacology, etc. Two to three years of direct research experience with sound publication records is required, Broad knowledge and experimental skills are necessary. The successful candidate will have demonstrated ability to work in team-oriented matrix structures, and have strong communication skills in both oral and written English.
Post Doc Researcher
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
China Novartis Institutes for Biomedical Research Co. Ltd (CNIBR) is currently seeking to fill multiple 3-year term postdoctoral position in the Biology department. CNIBR offers a dynamic and stimulating research environment which involves multidisciplinary interactions. The postdoctoral researchers will also interact with the global Novartis postdoctoral program. We provide a highly competitive benefit and compensation package for the positions.
The successful candidate should have a Ph.D. degree in biology, biochemistry, cell biology, virology or related field with good molecular biology experiences. Excellent English and communication skills are required.
Tumor Models and Cancer Stem Cells: In developing drugs combating human cancers, tumor models are essential for studying mechanisms of cancer formation, as well as for testing drug candidates. Growing body of evidence suggests the presence of cancer stem cells (CSCs) in tumors. CSCs can be resistant to chemotherapy agents, and only represent a small fraction (2-5%) of cells in a tumor. They posses capacity of self-renewal and are able to differentiate into mature cells. We are performing studies to identify and characterize CSCs. We are also developing novel tumor models for cancer studies and efficacy testing of drug candidates. These studies will facilitate our understanding of growth controls in malignant tumors. In addition, it would serve as model system to understand the basic biology of tumor formation, and, to facilitate discovery and development of therapeutic candidates against cancer (or contact Dr. Z. Chen at zhi-1.chen@novartis.com).
Stem Cell Biology: Diseases caused liver injury often leads to liver dysfunction and organ failure. Stem cell research offers great promises of applying cell-based therapy and liver regeneration to replace damaged tissue as a means to treat liver diseases. Using integrative approaches including genomics/systems biology, mouse and zebra fish genetics, high content image analysis, chemogenetics, and cutting-edge high through put screening technologies, we are setting up a research program to explore the molecular mechanism underlying stem cell hepatogenic differentiation and liver regeneration. In particular, we are interested in how BMP regulates stem cell pluripotency and hepatogenic lineage progression as well as developing a MTS phenotypic screen to identify molecules that promotes or inhibits stem cell originated hepatocyte differentiation. (or contact Dr. J Shou at Jianyong.shou@novartis.com)
Virology: Hepatitis B virus is a major health problem in China. We are interested in characterizing the unique process of HBV virus assembly and release from host cells. We will investigate the biological functions of viral envelop proteins and their interaction with cellular factors that regulate the viral assembly and egress pathway. Through the study, we will identify novel antiviral targets and elucidate the mechanisms of HBV life cycle. Students with excellent publication record and experiences with intracellular membrane trafficking and HBV research are preferred. (or contact Dr. G. Yang at guang-2.yang@novartis.com)
Virology/epigenetics: Successful treatment of HBV infection hinges on the inactivation or removal of viral replication template which is an episomal, covalently closed and circularized (ccc) double strand DNA (cccDNA) found in cell nucleus. cccDNA is stably maintained as nucleosome attached with H3 and H4 histones. It is shown that acetylation of H3 and H4 histone is related to the activation of viral transcription and replication. We hypothesize that treatment related innate immune activity is able to induce deacetylation of histone proteins in cccDNA nucelosomes and subsequently shuts down viral production. The aim of this study is to investigate the interplays among host innate immune response, deacetylation of cccDNA nucleosome and HBV replication and maintenance. (or contact Dr. T Zhou, tianlun.zhou@novartis.com)
Epigenetics: Epigenetics describe heritable changes in genome function that are not coded in the primary DNA sequence. Many diseases are driven by both genetic and epigenetic abnormalities. Epigenetic alternations in diseases can be reversed, thus represents a new frontier of medicine and will provide innovative therapeutic targets for drug discovery. The Epigenetics Research Program at the CNIBR is being focused on the following areas: Chromatin and transcription regulation, Stem cells biology, Immune modulation, Epigenetic mechanisms for cancer and other diseases. (or contact Dr. H. Chan, Homan.chan@novartis.com)
Minimum requirements
The successful candidate should have a Ph.D. degree in biology, biochemistry, cell biology, virology or related field with good molecular biology experiences. Excellent English and communication skills are required.
Senior Scientist II
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
The BM Senior Scientist will be responsible for the screening, characterization and selection of antibodies and for the development of biomarker assays based on Immunohistochemistry. She or he will set up and apply related technical operations (e.g., Tissue Processing and Immunohistochemistry Staining Workstation), perform tissue staining with antibodies, and image and data analysis. Additionally, the person will participate in study report writing.
Keyword: CNIBR 35679BR
Minimum requirements
•Ph.D. in Immunology/Cell Biology/Pathology.
•Advanced English language skills mandatory.
•Experience in Immunology and immunoassays.
•Practical experience in immunohistochemistry staining and associated image analysis, quality control and documentation, preferably in a company/central service setting.
•Multi-tasking, good communication skills and team work spirit are required.
Biomarker Development Expert
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
The BM Expert will be responsible to manage external collaborations for BMD Center Shanghai, involved with generating Biomarker analytical tools and analytics for Novartis drug development programs. Focus is to supervise relationships with external partners to achieve high quality deliverables and data by ensuring sound scientific and technical work-orders, tracking of work conduct and evaluation of deliverables. Additionally, the person will be responsible to ensure appropriate contracts are in place and for internal tracking of contracts and related funding. Further it is expected the person performs vendor audits, pro-actively explores opportunities and contributes to scientific and technical knowledge base of BMD Shanghai. This activity will be performed in close collaboration with the scientific experts in the different work areas and with CNIBR Business Development and Quality Assurance.
Minimum requirements
• The challenging position needs a mature person, with strong scientific and technical background, paired with strong organization, multi-tasking and teamwork skills. The person in charge of this position needs creativity to find solutions within given limits, as well as acceptance of administrative demands.
• Experience in project management in a service environment, preferentially in Diagnostics or Bioanalytics (e.g. CRO) is a key asset.
• Experience with TQM and experience outside China are a plus.
• Work experience should be 4 years plus after PhD, preferentially with leadership experience. Educational Background in Medicine/ Diagnostics/ Biochemistry/ Bioanalytics. Further education in management and administration is a plus.
• Advanced English language skills are mandatory.
Biomarker Expert(Lab head)
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
• Be responsible for the generation and application of bioanalytical tools for preclinical and clinical studies to support R&D programs.
• Perform Validation of analytical methods according appropriate quality standard and BM analysis for multiple preclinical and clinical studies.
• Interpret and report the biomarkers analysis data to support clinical studies.
• Explore and develop core capabilities in Biomarker analysis with classical and cutting edge technology (such as ELISA, Luminex, multiplexed assays, biochip, etc).
• Collaborate with BMD core team and external partners to explore the identification and confirmation of Biomarkers in related disease areas.
• Contribute and manage the internal and external collaborations to support Novartis development programs.
Minimum requirements
• Ph.D in immunology, molecular biology, or biochemistry plus 3-5 years of solid laboratory leadership experience.
• Have experience to design and invent immunoassays(ELISA, etc.) and other bioanalytical methods(LC/MS).
• Have proven capability for taking multiple tasks and planning the projects progress.
• Excellent written and oral communication skills in English are essential.
• Additional experience in clinical diagnostics, cancer and infectious disease as a plus.
Senior Scientist II
工作地点： 上海
招聘人数： 1
联系人：人力资源部
EMAIL：recruit_cnibr.phcnzj@novartis.com
Job Description
The BM Senior Scientist will be responsible for the screening, characterization and selection of antibodies and for the development of biomarker assays based on flow cytometry. She or he will set up and apply related technical operations (e.g. flow cytometer), perform cell staining with antibodies, FACS (cell sorting) and data analysis. Additionally, the person will participate in study report writing.
Keyword:CNIBR 35936BR
Minimum requirements
• Ph.D.in Immunology/Cell Biology/Histology.
• Advanced English language skills mandatory.
• Experience in Immunology and immunoassays.
• Practical experience with flow cytometer operation, immunofluorescence staining, cell sorting and data analysis, quality control and documentation, preferably in a company/central service setting.
• Multi-tasking, good communication skills and team work spirit are required
Research Assistants/Technicians at Novartis-Fudan Joint Research Laboratory (JRL) on Fenglin Campus of Fudan University
实验室助理/技术员 诺华-复旦联合实验室(位于复旦大学生物医学研究院)
工作地点： 上海
招聘人数： 1
联系人：anna
EMAIL：anna.ma@novartis.com
职位职责：
We are recruiting enthusiastic associates to join JRL between Novartis R&D Center and Fudan University.
You must be highly motivated, self-driven, and dedicated to discovery and development of therapeutic drugs. Advanced skills in laboratory and hand-on experience in experimental design, trouble-shooting and data analysis are required. Candidate shall be able to communicate efficiently in both Chinese and English. Excellent interpersonal skills and team-work spirit are needed. Previous working experience in a team setting is a plus.
诺华中国研发中心和复旦大学生物医学研究院联合成立的实验室希望吸引有志于医药研究领域的人士应聘该职位. 应聘者应具备自动自发的科研精神, 实验设计分析和解决问题的经验, 善于在团队环境工作以及能用中英文沟通.
应聘要求：
You are expected to have a Bachelor Degree or equivalent certificate in one of the following areas: Molecular/Cellular Biology, Biochemistry, Medicine, Pharmacology or Animal Sciences. 1- 2 year experience in laboratory research is required. You need to have proven competences in standard techniques, including DNA/RNA/Protein manipulations, PCR analysis, cell culture and transfections, expression analysis, and computer skills. Candidates with hand-on experience working with small animals and histology are strongly encouraged to apply. Ideally, you will possess skills in creativity, problem-solving, logic thinking and team-work.
1. 学士学位或相等学力;
2. 专业: 分子/细胞生物学.生物化学,医学,药学和动物学;
3. 1-2年实验室经验;
4. 掌握实验室技术如: DNA/RNA/蛋白操作, PCR, 细胞培养和转染,表达分析和基础生物和办公软件应用;
欢迎具备小动物操作和组织学工作经验的人士申请 |
