General Information
- Project ID
- OEP002902
- Project Name
- Analysis of blood methylation quantitative trait loci in East Asians identifies ancestry-specific effects associated with complex trait variation
- Description
- This project has included individual-level genotype data (SNP chip, methy_3523_qc0.01.bed,bim,fam) and DNA methylation data (Illumina EPIC, methy_3523.rdata) of 3523 Han Chinese (NSPT), and also the individual-level genotype data (SNP chip, 200505_960Sps_passed.vcf) and DNAm data (Illumina EPIC, beta_norm.rda) of additional 798 individuals (CGZ), which are in controlled access. The individual-level genotype data is not available because of IRB restriction due to privacy concern. The individual-level DNA methylation data can be available with reasonable requests. The project also included mQTL summary statistics (cis1_10.zip, cis11_22.zip, lcis.zip, trans.zip) with threshold of 1e-10 in 3523 Han Chinese (NSPT), SNP information (effect allele equals to minor allele, and effect allele frequency) in NSPT (snp_chr1_22.info.zip), the replication for these mQTLs (CGZ_mQTL.rep2.csv) in the CGZ cohort, and blood cell-lineage (lymphoid- and myeloid-) mQTLs estimated by using CELLDMC (cts_mQTL_info.Rd). These data are available for download. Data usage shall be in full compliance with the Regulations on Management of Human Genetic Resources in China. Use of this data requires a citation of our article. For controlled access data, requests are normally processed within two weeks. A template of the data sharing and confidentiality agreement will be sent to the applicant, and the data can be used within the permitted scope after the data sharing and confidentiality agreement has been signed.
- Publications
-
Analysis of blood methylation quantitative trait loci in East Asians identifies ancestry-specific effects associated with complex trait variation
Peng, Qianqian et al. “Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits.” Nature genetics, 10.1038/s41588-023-01494-9. 19 Apr. 2024
(PMID: 38641644) (DOI: 10.1038/s41588-023-01494-9)
Project information
Author Information
- Create Date
- 2021-11-16
- Last Modified
- 2024-05-09
- Submission
- Sijia Wang
- Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences