韩敬东


韩敬东:研究员、研究组长、博士生导师、所长、计算生物学重点实验室主任

联系方式

电子邮件 : jdhan@picb.ac.cn

课题组主页: http://www.picb.ac.cn/hanlab

研究方向

•分子系统生物学


研究领域

主要从事分子系统生物学研究工作,具体包括:(1) 研究生物网络的结构、动态及其功能;(2) 通过表观组学、功能基因组学及整合网络分析,寻找衰老及干细胞分化相关的关键基因,并进一步研究分子及功能作用机制;(3) 探求遗传基因网络中内在的安全稳定机制。

个人简介

2012.10-至今,上海科技大学生命科学与技术学院,教授

2010.09-至今,中科院计算生物学重点实验室,主任

2010.09-至今,中科院上海生科院计算生物学研究所,所长、研究员

2005.03-2010.08,中科院遗传与发育生物学研究所,分子系统中心主任、研究员

2002.09-2005.03,美国哈佛大学医学院,博士后

2001.07-2002.08,美国CQOS公司,工程师

2000.07-2001.06,美国Rare Medium公司,软件开发

1999.01-2000.06,美国NorthStar科技公司,工程师

1997.06-1998.12,美国洛克菲勒大学,博士后

获奖情况

2015年,上海市领军人才

2014年,国家百千万人才工程,并获得国家“有突出贡献中青年专家”荣誉称号

2011年, 上海市学术带头人

2009 年,百人计划终期评估优秀

2006 年,国家自然科学基金委员会杰出青年基金

2005 年,中科院百人计划

代表论文

1. Lei Hou^, Dan Wang^, Di Chen^, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, and William B. Mair and Jing-Dong J. Han*. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction.Cell Metabolism, 2016, 8;23(3):529-40.

2. Yi Huang, Xiaoming Yu, Na Sun, Nan Qiao, Yaqiang Cao, Jerome D. Boyd-Kirkup, Qin Shen, and Jing-Dong J Han. Single-cell level spatial gene expression in the embryonic neural differentiation niche. Genome Research. 2015 Apr;25(4):570-81.

3. Weiyang Chen1, Wei Qian1, Gang Wu1, Weizhong Chen1, Bo Xian1, Xingwei Chen1, Yaqiang Cao1, Christopher D Green1, Fanghong Zhao2, Kun Tang1 and Jing-Dong J. Han1,*,Three-dimensional human facial morphologies as robust aging markers, Cell Research, 2015, 25:574-587 (highlighted by Nature Press Release, Science News, New Scientists, The Guardian, Daily Mail, and NewsWeek, etc).

4. Weizhong Chen1,2†, Yi Liu1,3†, Shanshan Zhu1, Christopher D. Green1, Gang Wei1, Jing-Dong J. Han1,*, Improved Nucleosome Positioning Algorithm iNPS for Accurate Nucleosome Positioning from Sequencing Data,Nature Communications 2014, doi:10.1038/ncomms5909.

5. Ming Su^, Dali Han^, Jerome D Boyd-Kirkup, Xiaoming Yu and Jing-Dong J Han*,Evolution of Alu towards enhancers, Cell Reports, 2014, 7(2): 376-385

6. Jin’e Li^, Yi Liu^, Min Liu and Jing-Dong J Han*,Functional dissection of regulatory models using gene expression data of deletion mutants, PLoS Genetics, 2013, 9(9): e1003757.

7. Wei Zhang^, Yi Liu^, Na Sun, Dan Wang, Jerome Boyd-Kirkup, Xiaoyang Dou, Jing-Dong J Han*, Integrating Genomic, Epigenomic and TranscriptomicFeatures Reveals Modular Signatures UnderlyingPoor Prognosis in Ovarian Cancer, Cell Reports, 2013, 4(3):542–553

8. Yi Liu^, Nan Qiao^, Shanshan Zhu, Ming Su, Na Sun, Jerome Boyd-Kirkup, Jing-Dong J. Han*. A novel Bayesian network inference algorithm for integrative analysis of heterogeneous deep sequencing data. Cell Research. 2013 Mar;23(3):440-3.

9. Zhou, B., Yang, L., Li, S.F., Huang, J.L., Chen, H.Y., Hou, L., Wang, J.B., Green, C.D., Yan, Z., Huang, X., Zhu L., Xiao H.S., Liu Y. *, and Han J.D.J. * (2012). Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions,ProcNatlAcadSci U S A. 8;109(19):E1201-9.

10. Jin, C., Li, J., Green, C.D., Yu, X., Tang, X, Han, D., Xian, Bo., Wang, D, Huang, X., Cao, X., Yan. Z., Hou, L., Liu, J., Shukeir, N., Khaitovich, P., Chen, C.D., Zhang, H., Jenuwein, T. and  Han, J.-D.J *,Histone Demethylase UTX-1 Regulates C. elegans Lifespan by Targeting Insulin/IGF-1 Signaling Pathway, Cell Metabolism, 2011, 14: 161-172.