Detail
Experiment ID:
EXP00031
Reference:
- Title: Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma.
- Author: Guo Y, Chen Z, Zhang L, Zhou F, Shi S, Feng X, Li B, Meng X, Ma X, Luo M, Shao K, Li N, Qiu B, Mitchelson K, Cheng J, He J
- Journal: Cancer research.2008 Jan 01;68(1):26-33.doi:10.1158/0008-5472.CAN-06-4418.
- Abstract: Esophageal cancer is the sixth leading cause of death from cancer and one of the least studied cancers worldwide. The global microRNA expression profile of esophageal cancer has not been reported previously. Here, for the first time, we have investigated expressed microRNAs in cryopreserved esophageal cancer tissues using advanced microRNA microarray techniques. Our microarray analyses identified seven microRNAs that could distinguish malignant esophageal cancer lesions from adjacent normal tissues. Some microRNAs could be correlated with the different clinicopathologic classifications. High expression of hsa-miR-103/107 correlated with poor survival by univariate analysis as well as by multivariate analysis. These results indicate that microRNA expression profiles are important diagnostic and prognostic markers of esophageal cancer, which might be analyzed simply using economical approaches such as reverse transcription-PCR.
- PMID: 18172293
Expression Profile:
- Description:Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma
- Organism:Homo sapiens
- Source:GEO
- Source ID:GSE6188
- Platform: GPL4508
- Number of samples:257
- Overall design:cancer vs adjacent normal tissues
- Instrument:Tsinghua University mammalian 2K microRNA microarray
Design and Sample:
- Cancer Type:esophageal cancer
- Cancer SubType:N/A
- Cell Line:N/A
- Experimental Design:cancer vs normal
- Case Sample:cancer tissue
- Control Sample:adjacent normal tissue
- Num of Case:153
- Num of Control:104
- Quantification Software:Limma
- Num of miRNAs:294
Identification:
- Num of Up:91
- Num of Down:86
Time Info:
- Create Time2016-03-14
- Update Time:2021-05-27
Status:
| miRNA ID | Cancer Type | Design | logFC | AveExpr | T value | P value | adj Pvalue | Status | Plot |
|---|