We hope this database will be a useful resource for:

  • Estimation of all main cell-type fractions in a given tissue
  • Detection of differentially methylated cytosines independent of cell-type composition
  • Detection of cell-type specific differential DNAm

Suggested tools to run cell-type deconvolution:

Note: For both tools, the DNAm-atlas reference matrices are pre-installed in the package/web server and can be applied directly.


Each tissue name links to the download of a reference matrix csv file


  • Zhu, T., Liu, J., Beck, S., Pan, S., Capper, D., Lechner, M., Thirlwell, C., Breeze, C. E., & Teschendorff, A. E. (2022). A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution. Nature methods, 19(3), 296–306. https://doi.org/10.1038/s41592-022-01412-7
  • Teschendorff, A. E., Zhu, T., Breeze, C. E., & Beck, S. (2020). EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data. Genome biology, 21(1), 221. https://doi.org/10.1186/s13059-020-02126-9


Email: zhutianyu2018@sinh.ac.cn