General Information
- Analysis ID
- OEZ008120
- Analysis Name
- Analysis of blood methylation quantitative trait loci in East Asians identifies ancestry-specific effects associated with complex trait variation
- Description
- Methylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA methylation changes in genetic predisposition, yet they have not been fully characterized in East Asians. We identified mQTLs in whole blood from 3,523 Chinese individuals and replicated them in additional 1,858 Chinese individuals from two cohorts. Over 9% of mQTLs displayed specificity to East-Asians, facilitating the fine-mapping of EA-specific genetic associations, as shown for variants associated with height. Trans-mQTLs hotspots revealed biological pathways contributing to EA-specific genetic associations, including an ERG-mediated 233 trans-mCpG network, implicated in hematopoietic cell differentiation, which reflects binding efficiency modulation of the ERG protein complex. More than 90% of mQTLs were shared between different blood cell-lineages, with the smaller fraction of lineage-specific mQTLs displaying preferential hypomethylation in the respective lineages. Our study provides new insights into the mQTL landscape across ethnicities and their downstream effects on cellular processes and diseases/traits.
- Publications
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Analysis of blood methylation quantitative trait loci in East Asians identifies ancestry-specific effects associated with complex trait variation
Analysis Information
Target
Analysis Data
Submitter Information
- Create Date
- 2021-11-16
- Last Modified
- 2023-06-15
- Submission
- Sijia Wang