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Single cell gene_expression
Analysis type
Other
OEZ013253
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Acid mine drainage virome
Description
Viral sequences identified from metagenomes and genomes data across global acid mine drainage.
Analysis typeSequence Annotation
OEZ008166
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SMAG_MAGs
Description
SMAG catalog
Analysis typeOther
OEZ014109
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gene_express
Analysis type
Other
OEZ014114
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Analysis of blood methylation quantitative trait loci in East Asians identifies ancestry-specific effects associated with complex trait variation
Description
Methylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA methylation changes in genetic predisposition, yet they have not been fully characterized in East Asians. We identified mQTLs in whole blood from 3,523 Chinese individuals and replicated them in additional 1,858 Chinese individuals from two cohorts. Over 9% of mQTLs displayed specificity to East-Asians, facilitating the fine-mapping of EA-specific genetic associations, as shown for variants associated with height. Trans-mQTLs hotspots revealed biological pathways contributing to EA-specific genetic associations, including an ERG-mediated 233 trans-mCpG network, implicated in hematopoietic cell differentiation, which reflects binding efficiency modulation of the ERG protein complex. More than 90% of mQTLs were shared between different blood cell-lineages, with the smaller fraction of lineage-specific mQTLs displaying preferential hypomethylation in the respective lineages. Our study provides new insights into the mQTL landscape across ethnicities and their downstream effects on cellular processes and diseases/traits.
Analysis typeOther
OEZ008120
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PMN.rds
Analysis type
Other
OEZ014108
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PMN_rawcounts.mtx.gz
Analysis type
Other
OEZ014107
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PMN_meta_data.csv
Analysis type
Other
OEZ014106
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PMN_projected_cell_annotation.csv
Analysis type
Other
OEZ014105
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OEZ_2303021024
Description
Summary statistic of hair whorl direction
Analysis typeOther
OEZ013261