Analysis typeOther
OEZ014368
Analysis typeDe Novo Assembly
OEZ013235
Analysis typeOther
OEZ005406
Descriptiontest analysis data security
Analysis typeDe Novo Assembly
OEZ014366
Analysis typeDe Novo Assembly
OEZ014104
Analysis typeOther
OEZ013176
DescriptionArcobacteraceae MAGs were obtained from wood-falls (Kalenitchenko, D., Dupraz, M., Le Bris, N., Petetin, C., Rose, C., West, N. J.Galand, P. E. (2016) Ecological succession leads to chemosynthesis in mats colonizing wood in sea water. The ISME journal. 10, 2246-2258.;Kalenitchenko, D., Le Bris, N., Dadaglio, L., Peru, E., Besserer, A.Galand, P. E. (2017) Bacteria alone establish the chemical basis of the wood-fall chemosynthetic ecosystem in the deep-sea. The ISME journal. 12, 367-379.). These were reassembled in this study using MetaSPAdes v3.13.0 with the settings “-k 21,33,55”.
Analysis typeDe Novo Assembly
OEZ014276
Description249 of MAGs were obtained from the 63 metagenomic data of sinking particulate organic matter collected by sediment traps at abyssal depths at ALOHA (Boeuf, D., Edwards, B. R., Eppley, J. M., Hu, S. K., Poff, K. E., Romano, A. E., Caron, D. A., Karl, D. M.DeLong, E. F. (2019) Biological composition and microbial dynamics of sinking particulate organic matter at abyssal depths in the oligotrophic open ocean. Proceedings of the National Academy of Sciences. 116, 11824-11832.). These were reassembled in this study using MetaSPAdes v3.13.0 with the settings “-k 21,33,55”.
Analysis typeDe Novo Assembly
OEZ014275
DescriptionIgA nephropathy (IgAN) is a major cause of kidney failure worldwide. Here we investigated the contribution of genome-wide protein coding variants to IgAN risk by performing a three-stage exome chip-based association study in 8,529 IgAN patients and 23,224 healthy controls of Han Chinese ancestry. We discovered a novel rare nonsynonymous risk variant in VEGFA, and further sequencing of VEGFA revealed twice as many carriers of other rare variants in 2,148 IgAN cases compared to 2,732 controls. We also discovered a common nonsynonymous risk variant in PKD1L3, and the variant was shown to be associated with nearby HP gene expression and lower protein level by previous and current studies. However, a common loss-of-function mutation of PKD1L3 did not show any association, suggesting that HP is more likely to be a susceptibility gene for IgAN. Our discovery of VEGFA and HP has expanded understanding on the genetic basis of IgAN susceptibility.
Analysis typeOther
OEZ013225
DescriptionThe metabolite data of Rugao 2019-follow up
Analysis typeOther
OEZ014274