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  • superQ_PEM-seq_TRB

    Yuefeng Guo, , 2023.08.20

    Description

    The superQ pipeline (https://github.com/liumz93/superQ/) was used to identify the integration events. Briefly, after the adapter and low-quality sequence trimming using cutadapt (https://cutadapt.readthedocs.io/), the remaining sequences were aligned to the hg38 genome using bowtie2 (https://bowtie-bio.sourceforge.net/bowtie2/). The PCR duplication was removed by the molecular barcode.

    Analysis type

    Reference Alignment

    OEZ014268

  • superQ_PEM-seq_TRD

    Yuefeng Guo, , 2023.06.25

    Description

    The superQ pipeline (https://github.com/liumz93/superQ/) was used to identify the integration events. Briefly, after the adapter and low-quality sequence trimming using cutadapt (https://cutadapt.readthedocs.io/), the remaining sequences were aligned to the hg38 genome using bowtie2 (https://bowtie-bio.sourceforge.net/bowtie2/). The PCR duplication was removed by the molecular barcode.

    Analysis type

    Reference Alignment

    OEZ014115

  • OEZ_Yan-na_2207250917

    Yan-na Wang, , 2022.07.25

    Description

    Multiple genome-wide association studies (GWASs) have identified the MTMR3/HORMAD2/LIF/OSM region to be associated with IgA nephropathy (IgAN), but the causal variants, implicated genes, and altered functions are poorly understood. Here, we performed fine-mapping analyses based on the GWAS datasets consisting of 2,762 IgAN cases and 5,803 controls. We identified two variants explaining the entire GWAS signal, rs4823074 and rs16988135, both of which linked to the MTMR3 promoters in B-lymphoblastoid cells. Mendelian randomization studies suggested that the risk alleles may modulate disease susceptibility by affecting serum IgA levels through increased MTMR3 expression. Consistently, we observed elevated MTMR3 expression in PBMCs from IgAN patients. Further mechanistic studies in vitro demonstrated that MTMR3 increased IgA production dependent upon its PtdIns3P binding domain. Moreover, our study provided the in vivo functional evidence that Mtmr3−/− mice exhibited defective TLR9-induced IgA production and glomerular IgA deposition. Collectively, the present study indicated the role of MTMR3 in IgAN pathogenesis by enhancing TLR9-induced IgA immunity, and provided novel insights into using genetic data to explore a novel intervention target for IgAN.

    Analysis type

    Other

    OEZ009584

  • CryoEM

    Wenzhi Xue, , 2023.08.18

    Description

    CryoEM

    Analysis type

    De Novo Assembly

    OEZ014267

  • human proteome microarray

    Jing Zhong, Shanghai University of Traditional Chinese Medicine, 2023.08.12

    Description

    The median fluorescence signal at each site (F635_Median) was divided by the background (B635_Median) for data analysis, that is, original signal strength (I) = F635_Median/B635_Median. The median and SD of I were calculated to obtain the corrected data Z-Score (corrected signal strength) for each site. Proteins with a Z-Score greater than 2.8 were those that bind to HDCA. The mean value (I mean) represents the mean value of the original signal strength of each protein. I Mean-Ratio is the ratio between the Biotin-HDCA group and Biotin group. To call the candidates, the cutoff was set as a P value≤0.05 and I Mean-Ratio≥1.4.

    Analysis type

    De Novo Assembly

    OEZ014266

  • OEZ_Wenyun_2307281403

    Wenyun Guo, , 2023.07.28

    Analysis type

    De Novo Assembly

    OEZ014264

  • Single cell gene_expression

    Mao Zhang, , 2023.02.16

    Analysis type

    Other

    OEZ013253

  • Acid mine drainage virome

    Zhenghua Liu, , 2021.12.08

    Description

    Viral sequences identified from metagenomes and genomes data across global acid mine drainage.

    Analysis type

    Sequence Annotation

    OEZ008166

  • SMAG_MAGs

    Caiyu Lu, , 2023.06.14

    Description

    SMAG catalog

    Analysis type

    Other

    OEZ014109

  • gene_express

    fan wang, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 2023.06.18

    Analysis type

    Other

    OEZ014114