General Information
- Project ID
- OEP000760
- Project Name
- Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia
- Description
- T-cell acute lymphoblastic leukemia (T-ALL) is a clonal malignancy of immature T cells. Recently, the next-generation sequencing approach has allowed systematic identification of molecular features in pediatric T-ALL. Here, by performing RNA-sequencing and other genomewide analysis, we investigated the genomic landscape in 61 adult and 69 pediatric T-ALL cases. Thirty-six distinct gene fusion transcripts were identified, with SET-NUP214 being highly related to adult cases. Among 18 previously unknown fusions, ZBTB16-ABL1, TRA-SALL2, and involvement of NKX2-1 were recurrent events. ZBTB16-ABL1 functioned as a leukemogenic driver and responded to the effect of tyrosine kinase inhibitors. Among 48 genes with mutation rates >3%, 6 were newly found in T-ALL. An aberrantly overexpressed short mRNA transcript of the SLC17A9 gene was revealed in most cases with overexpressed TAL1, which predicted a poor prognosis in the adult group. Up-regulation of HOXA, MEF2C, and LYL1 was often present in adult cases, while TAL1 overexpression was detected mainly in the pediatric group. Although most gene fusions were mutually exclusive, they coexisted with gene mutations. These genetic abnormalities were correlated with deregulated gene expression markers in three subgroups. This study may further enrich the current knowledge of T-ALL molecular pathogenesis.
- Publications
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Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia
Chen B, Jiang L, Zhong ML, et al. Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia [published correction appears in Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):23192]. Proc Natl Acad Sci U S A. 2018;115(2):373-378.
(PMID: 29279377) (DOI: 10.1073/pnas.1717125115) - Related Links
- https://www.pnas.org/content/115/2/373.long
Project information
- Experiments
- 1
Experiment ID Experiment name Experiment type Create Date OEX002233 Transcriptomic Transcriptomic 2020-02-16 - Samples
- 130
Sample ID Sample Name Sample Subject Type Organism Tissue Create Date OES025840 A1 Human Homo sapiens bone marrow 2020-02-16 OES025841 A10 Human Homo sapiens bone marrow 2020-02-16 OES025842 A11 Human Homo sapiens bone marrow 2020-02-16 OES025843 A12 Human Homo sapiens bone marrow 2020-02-16 OES025844 A13 Human Homo sapiens bone marrow 2020-02-16 OES025845 A14 Human Homo sapiens bone marrow 2020-02-16 OES025846 A15 Human Homo sapiens bone marrow 2020-02-16 OES025847 A16 Human Homo sapiens bone marrow 2020-02-16 OES025848 A17 Human Homo sapiens bone marrow 2020-02-16 OES025849 A18 Human Homo sapiens bone marrow 2020-02-16 OES025850 A19 Human Homo sapiens bone marrow 2020-02-16 OES025851 A2 Human Homo sapiens bone marrow 2020-02-16 OES025852 A20 Human Homo sapiens bone marrow 2020-02-16 OES025853 A21 Human Homo sapiens bone marrow 2020-02-16 OES025854 A22 Human Homo sapiens bone marrow 2020-02-16 OES025855 A23 Human Homo sapiens bone marrow 2020-02-16 OES025856 A24 Human Homo sapiens bone marrow 2020-02-16 OES025857 A25 Human Homo sapiens bone marrow 2020-02-16 OES025858 A26 Human Homo sapiens bone marrow 2020-02-16 OES025859 A27 Human Homo sapiens bone marrow 2020-02-16 OES025860 A28 Human Homo sapiens bone marrow 2020-02-16 OES025861 A29 Human Homo sapiens bone marrow 2020-02-16 OES025862 A3 Human Homo sapiens bone marrow 2020-02-16 OES025863 A30 Human Homo sapiens bone marrow 2020-02-16 OES025864 A31 Human Homo sapiens bone marrow 2020-02-16 OES025865 A32 Human Homo sapiens bone marrow 2020-02-16 OES025866 A33 Human Homo sapiens bone marrow 2020-02-16 OES025867 A34 Human Homo sapiens bone marrow 2020-02-16 OES025868 A35 Human Homo sapiens bone marrow 2020-02-16 OES025869 A36 Human Homo sapiens bone marrow 2020-02-16 OES025870 A37 Human Homo sapiens bone marrow 2020-02-16 OES025871 A38 Human Homo sapiens bone marrow 2020-02-16 OES025872 A39 Human Homo sapiens bone marrow 2020-02-16 OES025873 A4 Human Homo sapiens bone marrow 2020-02-16 OES025874 A40 Human Homo sapiens bone marrow 2020-02-16 OES025875 A41 Human Homo sapiens bone marrow 2020-02-16 OES025876 A42 Human Homo sapiens bone marrow 2020-02-16 OES025877 A43 Human Homo sapiens bone marrow 2020-02-16 OES025878 A44 Human Homo sapiens bone marrow 2020-02-16 OES025879 A45 Human Homo sapiens bone marrow 2020-02-16 OES025880 A46 Human Homo sapiens bone marrow 2020-02-16 OES025881 A47 Human Homo sapiens bone marrow 2020-02-16 OES025882 A48 Human Homo sapiens bone marrow 2020-02-16 OES025883 A49 Human Homo sapiens bone marrow 2020-02-16 OES025884 A5 Human Homo sapiens bone marrow 2020-02-16 OES025885 A50 Human Homo sapiens bone marrow 2020-02-16 OES025886 A51 Human Homo sapiens bone marrow 2020-02-16 OES025887 A52 Human Homo sapiens bone marrow 2020-02-16 OES025888 A53 Human Homo sapiens bone marrow 2020-02-16 OES025889 A54 Human Homo sapiens bone marrow 2020-02-16 OES025890 A55 Human Homo sapiens bone marrow 2020-02-16 OES025891 A56 Human Homo sapiens bone marrow 2020-02-16 OES025892 A57 Human Homo sapiens bone marrow 2020-02-16 OES025893 A58 Human Homo sapiens bone marrow 2020-02-16 OES025894 A59 Human Homo sapiens bone marrow 2020-02-16 OES025895 A6 Human Homo sapiens bone marrow 2020-02-16 OES025896 A60 Human Homo sapiens bone marrow 2020-02-16 OES025897 A61 Human Homo sapiens bone marrow 2020-02-16 OES025898 A7 Human Homo sapiens bone marrow 2020-02-16 OES025899 A8 Human Homo sapiens bone marrow 2020-02-16 OES025900 A9 Human Homo sapiens bone marrow 2020-02-16 OES025901 C1 Human Homo sapiens bone marrow 2020-02-16 OES025902 C10 Human Homo sapiens bone marrow 2020-02-16 OES025903 C11 Human Homo sapiens bone marrow 2020-02-16 OES025904 C12 Human Homo sapiens bone marrow 2020-02-16 OES025905 C13 Human Homo sapiens bone marrow 2020-02-16 OES025906 C14 Human Homo sapiens bone marrow 2020-02-16 OES025907 C15 Human Homo sapiens bone marrow 2020-02-16 OES025908 C16 Human Homo sapiens bone marrow 2020-02-16 OES025909 C17 Human Homo sapiens bone marrow 2020-02-16 OES025910 C18 Human Homo sapiens bone marrow 2020-02-16 OES025911 C19 Human Homo sapiens bone marrow 2020-02-16 OES025912 C2 Human Homo sapiens bone marrow 2020-02-16 OES025913 C20 Human Homo sapiens bone marrow 2020-02-16 OES025914 C21 Human Homo sapiens bone marrow 2020-02-16 OES025915 C22 Human Homo sapiens bone marrow 2020-02-16 OES025916 C23 Human Homo sapiens bone marrow 2020-02-16 OES025917 C24 Human Homo sapiens bone marrow 2020-02-16 OES025918 C25 Human Homo sapiens bone marrow 2020-02-16 OES025919 C26 Human Homo sapiens bone marrow 2020-02-16 OES025920 C27 Human Homo sapiens bone marrow 2020-02-16 OES025921 C28 Human Homo sapiens bone marrow 2020-02-16 OES025922 C29 Human Homo sapiens bone marrow 2020-02-16 OES025923 C3 Human Homo sapiens bone marrow 2020-02-16 OES025924 C30 Human Homo sapiens bone marrow 2020-02-16 OES025925 C31 Human Homo sapiens bone marrow 2020-02-16 OES025926 C32 Human Homo sapiens bone marrow 2020-02-16 OES025927 C33 Human Homo sapiens bone marrow 2020-02-16 OES025928 C34 Human Homo sapiens bone marrow 2020-02-16 OES025929 C35 Human Homo sapiens bone marrow 2020-02-16 OES025930 C36 Human Homo sapiens bone marrow 2020-02-16 OES025931 C37 Human Homo sapiens bone marrow 2020-02-16 OES025932 C38 Human Homo sapiens bone marrow 2020-02-16 OES025933 C39 Human Homo sapiens bone marrow 2020-02-16 OES025934 C4 Human Homo sapiens bone marrow 2020-02-16 OES025935 C40 Human Homo sapiens bone marrow 2020-02-16 OES025936 C41 Human Homo sapiens bone marrow 2020-02-16 OES025937 C42 Human Homo sapiens bone marrow 2020-02-16 OES025938 C43 Human Homo sapiens bone marrow 2020-02-16 OES025939 C44 Human Homo sapiens bone marrow 2020-02-16 OES025940 C45 Human Homo sapiens bone marrow 2020-02-16 OES025941 C46 Human Homo sapiens bone marrow 2020-02-16 OES025942 C47 Human Homo sapiens bone marrow 2020-02-16 OES025943 C48 Human Homo sapiens bone marrow 2020-02-16 OES025944 C49 Human Homo sapiens bone marrow 2020-02-16 OES025945 C5 Human Homo sapiens bone marrow 2020-02-16 OES025946 C50 Human Homo sapiens bone marrow 2020-02-16 OES025947 C51 Human Homo sapiens bone marrow 2020-02-16 OES025948 C52 Human Homo sapiens bone marrow 2020-02-16 OES025949 C53 Human Homo sapiens bone marrow 2020-02-16 OES025950 C54 Human Homo sapiens bone marrow 2020-02-16 OES025951 C55 Human Homo sapiens bone marrow 2020-02-16 OES025952 C56 Human Homo sapiens bone marrow 2020-02-16 OES025953 C57 Human Homo sapiens bone marrow 2020-02-16 OES025954 C58 Human Homo sapiens bone marrow 2020-02-16 OES025955 C59 Human Homo sapiens bone marrow 2020-02-16 OES025956 C6 Human Homo sapiens bone marrow 2020-02-16 OES025957 C60 Human Homo sapiens bone marrow 2020-02-16 OES025958 C61 Human Homo sapiens bone marrow 2020-02-16 OES025959 C62 Human Homo sapiens bone marrow 2020-02-16 OES025960 C63 Human Homo sapiens bone marrow 2020-02-16 OES025961 C64 Human Homo sapiens bone marrow 2020-02-16 OES025962 C65 Human Homo sapiens bone marrow 2020-02-16 OES025963 C66 Human Homo sapiens bone marrow 2020-02-16 OES025964 C67 Human Homo sapiens bone marrow 2020-02-16 OES025965 C68 Human Homo sapiens bone marrow 2020-02-16 OES025966 C69 Human Homo sapiens bone marrow 2020-02-16 OES025967 C7 Human Homo sapiens bone marrow 2020-02-16 OES025968 C8 Human Homo sapiens bone marrow 2020-02-16 OES025969 C9 Human Homo sapiens bone marrow 2020-02-16 - Runs
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130
Run ID Run Name Experiment Sample Data Num Create Date OER039723 A10 OEX002233 OES025841 2 2020-02-25 OER039724 A11 OEX002233 OES025842 2 2020-02-25 OER039725 A12 OEX002233 OES025843 2 2020-02-25 OER039726 A13 OEX002233 OES025844 2 2020-02-25 OER039727 A14 OEX002233 OES025845 2 2020-02-25 OER039728 A15 OEX002233 OES025846 2 2020-02-25 OER039729 A16 OEX002233 OES025847 2 2020-02-25 OER039730 A17 OEX002233 OES025848 2 2020-02-25 OER039731 A18 OEX002233 OES025849 2 2020-02-25 OER039732 A19 OEX002233 OES025850 2 2020-02-25 OER039733 A1 OEX002233 OES025840 2 2020-02-25 OER039734 A20 OEX002233 OES025852 2 2020-02-25 OER039735 A21 OEX002233 OES025853 2 2020-02-25 OER039736 A22 OEX002233 OES025854 2 2020-02-25 OER039737 A23 OEX002233 OES025855 2 2020-02-25 OER039738 A24 OEX002233 OES025856 2 2020-02-25 OER039739 A25 OEX002233 OES025857 2 2020-02-25 OER039740 A26 OEX002233 OES025858 2 2020-02-25 OER039741 A27 OEX002233 OES025859 2 2020-02-25 OER039742 A28 OEX002233 OES025860 2 2020-02-25 OER039743 A29 OEX002233 OES025861 2 2020-02-25 OER039744 A2 OEX002233 OES025851 2 2020-02-25 OER039745 A30 OEX002233 OES025863 2 2020-02-25 OER039746 A31 OEX002233 OES025864 2 2020-02-25 OER039747 A32 OEX002233 OES025865 2 2020-02-25 OER039748 A33 OEX002233 OES025866 2 2020-02-25 OER039749 A34 OEX002233 OES025867 2 2020-02-25 OER039750 A35 OEX002233 OES025868 2 2020-02-25 OER039751 A36 OEX002233 OES025869 2 2020-02-25 OER039752 A37 OEX002233 OES025870 2 2020-02-25 OER039753 A38 OEX002233 OES025871 2 2020-02-25 OER039754 A39 OEX002233 OES025872 2 2020-02-25 OER039755 A3 OEX002233 OES025862 2 2020-02-25 OER039756 A40 OEX002233 OES025874 2 2020-02-25 OER039757 A41 OEX002233 OES025875 2 2020-02-25 OER039758 A42 OEX002233 OES025876 2 2020-02-25 OER039759 A43 OEX002233 OES025877 2 2020-02-25 OER039760 A44 OEX002233 OES025878 2 2020-02-25 OER039761 A45 OEX002233 OES025879 2 2020-02-25 OER039762 A46 OEX002233 OES025880 2 2020-02-25 OER039763 A47 OEX002233 OES025881 2 2020-02-25 OER039764 A48 OEX002233 OES025882 2 2020-02-25 OER039765 A49 OEX002233 OES025883 2 2020-02-25 OER039766 A4 OEX002233 OES025873 2 2020-02-25 OER039767 A50 OEX002233 OES025885 2 2020-02-25 OER039768 A51 OEX002233 OES025886 2 2020-02-25 OER039769 A52 OEX002233 OES025887 2 2020-02-25 OER039770 A53 OEX002233 OES025888 2 2020-02-25 OER039771 A54 OEX002233 OES025889 2 2020-02-25 OER039772 A55 OEX002233 OES025890 2 2020-02-25 OER039773 A56 OEX002233 OES025891 2 2020-02-25 OER039774 A57 OEX002233 OES025892 2 2020-02-25 OER039775 A58 OEX002233 OES025893 2 2020-02-25 OER039776 A59 OEX002233 OES025894 2 2020-02-25 OER039777 A5 OEX002233 OES025884 2 2020-02-25 OER039778 A60 OEX002233 OES025896 2 2020-02-25 OER039779 A61 OEX002233 OES025897 2 2020-02-25 OER039780 A6 OEX002233 OES025895 2 2020-02-25 OER039781 A7 OEX002233 OES025898 2 2020-02-25 OER039782 A8 OEX002233 OES025899 2 2020-02-25 OER039783 A9 OEX002233 OES025900 2 2020-02-25 OER039784 C10 OEX002233 OES025902 2 2020-02-25 OER039785 C11 OEX002233 OES025903 2 2020-02-25 OER039786 C12 OEX002233 OES025904 2 2020-02-25 OER039787 C13 OEX002233 OES025905 2 2020-02-25 OER039788 C14 OEX002233 OES025906 2 2020-02-25 OER039789 C15 OEX002233 OES025907 2 2020-02-25 OER039790 C16 OEX002233 OES025908 2 2020-02-25 OER039791 C17 OEX002233 OES025909 2 2020-02-25 OER039792 C18 OEX002233 OES025910 2 2020-02-25 OER039793 C19 OEX002233 OES025911 2 2020-02-25 OER039794 C1 OEX002233 OES025901 2 2020-02-25 OER039795 C20 OEX002233 OES025913 2 2020-02-25 OER039796 C21 OEX002233 OES025914 2 2020-02-25 OER039797 C22 OEX002233 OES025915 2 2020-02-25 OER039798 C23 OEX002233 OES025916 2 2020-02-25 OER039799 C24 OEX002233 OES025917 2 2020-02-25 OER039800 C25 OEX002233 OES025918 2 2020-02-25 OER039801 C26 OEX002233 OES025919 2 2020-02-25 OER039802 C27 OEX002233 OES025920 2 2020-02-25 OER039803 C28 OEX002233 OES025921 2 2020-02-25 OER039804 C29 OEX002233 OES025922 2 2020-02-25 OER039805 C2 OEX002233 OES025912 2 2020-02-25 OER039806 C30 OEX002233 OES025924 2 2020-02-25 OER039807 C31 OEX002233 OES025925 2 2020-02-25 OER039808 C32 OEX002233 OES025926 2 2020-02-25 OER039809 C33 OEX002233 OES025927 2 2020-02-25 OER039810 C34 OEX002233 OES025928 2 2020-02-25 OER039811 C35 OEX002233 OES025929 2 2020-02-25 OER039812 C36 OEX002233 OES025930 2 2020-02-25 OER039813 C37 OEX002233 OES025931 2 2020-02-25 OER039814 C38 OEX002233 OES025932 2 2020-02-25 OER039815 C39 OEX002233 OES025933 2 2020-02-25 OER039816 C3 OEX002233 OES025923 2 2020-02-25 OER039817 C40 OEX002233 OES025935 2 2020-02-25 OER039818 C41 OEX002233 OES025936 2 2020-02-25 OER039819 C42 OEX002233 OES025937 2 2020-02-25 OER039820 C43 OEX002233 OES025938 2 2020-02-25 OER039821 C44 OEX002233 OES025939 2 2020-02-25 OER039822 C45 OEX002233 OES025940 2 2020-02-25 OER039823 C46 OEX002233 OES025941 2 2020-02-25 OER039824 C47 OEX002233 OES025942 2 2020-02-25 OER039825 C48 OEX002233 OES025943 2 2020-02-25 OER039826 C49 OEX002233 OES025944 2 2020-02-25 OER039827 C4 OEX002233 OES025934 2 2020-02-25 OER039828 C50 OEX002233 OES025946 2 2020-02-25 OER039829 C51 OEX002233 OES025947 2 2020-02-25 OER039830 C52 OEX002233 OES025948 2 2020-02-25 OER039831 C53 OEX002233 OES025949 2 2020-02-25 OER039832 C54 OEX002233 OES025950 2 2020-02-25 OER039833 C55 OEX002233 OES025951 2 2020-02-25 OER039834 C56 OEX002233 OES025952 2 2020-02-25 OER039835 C57 OEX002233 OES025953 2 2020-02-25 OER039836 C58 OEX002233 OES025954 2 2020-02-25 OER039837 C59 OEX002233 OES025955 2 2020-02-25 OER039838 C5 OEX002233 OES025945 2 2020-02-25 OER039839 C60 OEX002233 OES025957 2 2020-02-25 OER039840 C61 OEX002233 OES025958 2 2020-02-25 OER039841 C62 OEX002233 OES025959 2 2020-02-25 OER039842 C63 OEX002233 OES025960 2 2020-02-25 OER039843 C64 OEX002233 OES025961 2 2020-02-25 OER039844 C65 OEX002233 OES025962 2 2020-02-25 OER039845 C66 OEX002233 OES025963 2 2020-02-25 OER039846 C67 OEX002233 OES025964 2 2020-02-25 OER039847 C68 OEX002233 OES025965 2 2020-02-25 OER039848 C69 OEX002233 OES025966 2 2020-02-25 OER039849 C6 OEX002233 OES025956 2 2020-02-25 OER039850 C7 OEX002233 OES025967 2 2020-02-25 OER039851 C8 OEX002233 OES025968 2 2020-02-25 OER039852 C9 OEX002233 OES025969 2 2020-02-25 - Analysis
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1
Analysis ID Analysis Title Analysis Type Data Date OEZ014089 T-ALL expression Other 2 2023-05-17
Author Information
- Create Date
- 2020-02-16
- Last Modified
- 2021-06-10
- Submission
- Jinyan Huang
- Ruijin Hospital