General Information
- Project ID
- OEP004079
- Project Name
- Pancreatic ductal adenocarcinoma adjuvant chemotherapy vulnerability: a prospective observational study
- Description
- A prospective observational study enrolled 1,171 PDAC patients who had pancreatectomy is reported. After substantive follow-up and proteomic profiling of 191 patient samples, we identify functional modules with clinical relevance, establish a proteomic-level prognostic risk model for PDAC, and cross-validate the model using external as well as independent in-house cohorts. Two new biomarkers, indicative of PDAC adjuvant chemotherapy sensitivity, are discovered using integrated analysis of both clinical and proteomic datasets. Our prospective evidence points us towards a subgroup of patients to whom mild adjuvant chemo plan (for example S-1) might provide overall survival benefit.
Project information
- Experiments
- 1
Experiment ID Experiment name Experiment type Create Date OEX022973 PDAC_Phosphoproteomics Proteomic 2023-03-28 - Analysis
-
5
Analysis ID Analysis Title Analysis Type Data Date OEZ013888 PDAC_Proteomics_Spectronaut Other 1 2023-03-31 OEZ013890 PDAC_Phosphoproteomics_Library Other 49 2023-03-31 OEZ013891 PDAC_Proteomics_Library Other 109 2023-03-31 OEZ013892 PDAC_Proteomics_Spectronaut_Normalized Other 1 2023-03-31 OEZ013894 PDAC_PRM Other 2 2023-04-03
Author Information
- Create Date
- 2023-03-26
- Last Modified
- 2023-11-24
- Submission
- Chenxu Gao
- Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital