Bufalin Enhances Radiosensitivity of Esophageal Squamous Carcinoma Cells by Suppressing Homologous Recombination Repair Pathway
Description
Bufalin is a main component in toad venom, which is derived from the dry secretions of the posterior auricular gland and skin gland of the Chinese toad. It has a strong inhibitory effect on various solid tumors, including liver cancer, pancreatic cancer, colorectal cancer, gastric cancer, and bladder cancer. Based on the actual needs of patients with inoperable esophageal squamous cell carcinoma (ESCC) in middle and advanced stage, this study intends to combine bufalin with radiotherapy to guide radiotherapy for middle and advanced ESCC patients and explore the mechanism of bufalin in enhancing the radiosensitivity of ESCC.