This study analyzed two Chinese cohorts derived from a large Chinese population study, the Shanghai Changfeng Study, composing of individuals consecutively enrolled from Shanghai Changfeng Community, Shanghai from June 2009 to December 2012. Samples included Han Chinese individuals who were randomly sampled from the Shanghai Changfeng study and generated genome-wide DNA methylation profiles in the whole blood tissue. Changes in DNA methylation reflect effects of environmental changes on the human genome and may help us to explain the link between obesity and environmental factors.