DescriptionAlthough keratinocytes have been believed to exert critical functions in the pathogenesis of psoriasis, the relationship between keratinocytes and other cell types during the development of psoriasis remains elusive. How the MHC-II molecule in the keratinocyte influences the skin environment during the pathogenesis of psoriasis remains unclear. We constructed the epidermis-specific H2-Ab1 knockout mice and H2Ab1 deficiency in the keratinocyte significantly attenuated IMQ-induced inflammatory response. We also performed single-cell RNA-sequencing on the skin tissues of H2Ab1fl/fl mice and K14.H2Ab1fl/fl mice, which revealed the keratinocyte, NK, and DC clusters were significantly reduced in the skin with keratinocyte H2Ab1 deficiency. Therefore, targeting MHC-II could be a therapeutic target for psoriasis.
OEP004130
DescriptionSingle-cell analysis deciphers the tumor microenvironment remodeling associated with response to GOLP treatment in intrahepatic cholangiocarcinoma
OEP003206
Description
OEP004799
DescriptionIW(Inner Water)
OEP001556
DescriptionWe used metagenomic techniques to measure 10 amoeba strains, focusing on the possible health risks of endophytes present in them
OEP004802
Description
OEP004779
Description
OEP004775
DescriptionThe microbial diversity of hadal sediment from the Mariana Trench with increasing high hydrostatic pressure (HHP; 0.1, 40, 70, 90 and 115 MPa) during incubation using the (deep ocean experimental simulator) DOES system at a flow rate of 0.3 mL/min.
OEP004015
Description
OEP004778
DescriptionThis study analyzed two Chinese cohorts derived from a large Chinese population study, the Shanghai CF Study, composing of individuals consecutively enrolled from Shanghai CF Community, Shanghai from June 2009 to December 2012. Samples included Han Chinese individuals who were randomly sampled from the Shanghai CF study and generated genome-wide DNA methylation profiles in the whole blood tissue. Changes in DNA methylation reflect effects of environmental changes on the human genome and may help us to explain the link between obesity and environmental factors.
OEP004784