Description
OEP004489
Description
OEP004488
Description
OEP004485
DescriptionIW(Inner Water)
OEP001556
DescriptionAdenomyosis is a prevalent and non-cancerous uterine disease which can significantly impaired the fertility of reproductive-age women. However, the etiology, as well as the cellular and molecular mechanism underlying adenomyosis remain largely unknown. Here, we utilized cutting-edge spatial and single-cell RNA sequencing technologies to create a comprehensive transcriptional atlas of adenomyosis pathology. Our spatial profiling clearly distinguished gland, mesenchyma and myometrium regions, recapitulating spatial transcriptome structural characteristics of uterus. Moreover, we analyzed the expression profiles of 69,115 single cells and integrated them with spatial data. The analysis of immune cells showed a distinct immune inflammatory microenvironment in the eutopic and ectopic endometrial glands of adenomyosis. Notably, we discovered an increased number of DNAH9+ ciliated cells in ectopic endometrial glands, indicating their potential role in the formation of ectopic endometrium. These findings provide cellular evidence to support the invagination theory and offer a new vision on the pathophysiology and clinical intervention of adenomyosis.
OEP004165
DescriptionHere, we performed single-cell RNA sequencing of pre-treatment tumor samples in 26 patients with early-stage TNBC and 6 patients with advanced TNBC to define anti-PD-1 response-related components in the tumor microenvironment. Also, we performed RNA sequencing of pre-treatment tumor samples in 60 patients with early-stage TNBC receiving neoadjuvant anti-PD1 treatment.
OEP003394
DescriptionThe microbial diversity of hadal sediment from the Mariana Trench with increasing high hydrostatic pressure (HHP; 0.1, 40, 70, 90 and 115 MPa) during incubation using the (deep ocean experimental simulator) DOES system at a flow rate of 0.3 mL/min.
OEP004015
Description
OEP002590
DescriptionThe dataset contains mRNA expression (TPM) of 32 stage IV NSCLC patients (including LUAD and LUSC)
OEP004524
DescriptionNitrate-mediated sulfur-oxidizing communities
OEP004208