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PROJ
Analysis of blood methylation quantitative trait loci in East Asians identifies ancestry-specific effects associated with complex trait variation
Description
This project has included individual-level genotype data (SNP chip, methy_3523_qc0.01.bed,bim,fam) and DNA methylation data (Illumina EPIC, methy_3523.rdata) of 3523 Han Chinese (NSPT), and also the individual-level genotype data (SNP chip, 200505_960Sps_passed.vcf) and DNAm data (Illumina EPIC, beta_norm.rda) of additional 798 individuals (CGZ), which are in controlled access. The individual-level genotype data is not available because of IRB restriction due to privacy concern. The individual-level DNA methylation data can be available with reasonable requests. The project also included mQTL summary statistics (cis1_10.zip, cis11_22.zip, lcis.zip, trans.zip) with threshold of 1e-10 in 3523 Han Chinese (NSPT), the replication for these mQTLs (CGZ_mQTL.rep2.csv) in the CGZ cohort, and blood cell-lineage (lymphoid- and myeloid-) mQTLs estimated by using CELLDMC (cts_mQTL_info.Rd). These data are available for download. Data usage shall be in full compliance with the Regulations on Management of Human Genetic Resources in China. Use of this data requires a citation of our article. For controlled access data, requests are normally processed within two weeks. A template of the data sharing and confidentiality agreement will be sent to the applicant, and the data can be used within the permitted scope after the data sharing and confidentiality agreement has been signed.
OEP002902
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PROJ
N6-methyladenosine-dependent Sphingomyelin Metabolic Reprograming Promoted Immune Evasion in Pancreatic Cancer
Description
OEP005232
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PROJ
Untargeted LC-MS/MS analysis of DOM in Zhoushan
Description
Untargeted LC-MS/MS analysis of DOM in Zhoushan
OEP005175
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PROJ
Untargeted LC-MS/MS analysis of POM in Zhoushan
Description
Untargeted LC-MS/MS analysis of POM in Zhoushan
OEP005202
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PROJ
Effects of nutrient input on microorganisms in saline lake
Description
Global climate change and human activities have changed the salinity of the lake and the input of exogenous organic matter(OM) and nutrients into the lake.The input of nutrient elements will inevitably lead to changes in the microbial community of the salt lake. In order to explore the microorganisms that play a decisive role in the process of PE, this experiment was conducted.
OEP005013
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PROJ
Deciphering the composition and key driver genes of invasive micropapillary carcinoma (IMPC) by multi-omics analysis and multicenter retrospective cohort
Description
We delved into the intrinsic cellular components and transcriptomic signatures characterizing invasive micropapillary carcinoma (IMPC).Notably, we crafted a pioneering single-cell atlas of IMPC in human breast tissue, unraveling substantial heterogeneity predominantly driven by two distinct cell subsets: epithelioid cells and interstitial cells. Pseudotime analysis unveiled unique cell trajectories for IDC-NOS cells, epithelioid IMPC cells, and interstitial IMPC cells. Of significance, we found a significant positive correlation between KRT80 expression in IMPC and clinicopathological characteristics, such as lymph node metastasis and lymphatic vessel invasion. Additionally, high KRT80 expression was associated with shorter overall survival and disease-free survival times for IMPC patients in a multicenter retrospective cohort.
OEP005223
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PROJ
Mangrove plastisphere MAGs
Description
OEP004489
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PROJ
WGS of RB cell lines
Description
The WGS of RB cell lines
OEP005198
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PROJ
PCOS_RNA_Seq
Description
This project collected peripheral blood samples from four PCOS and four corresponding health controls. Integrated lncRNA, miRNA, and mRNA transcriptome analysis revealed key regulatory modules for polycystic ovary syndrome (PCOS).
OEP004667
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PROJ
The implication of the vaginal microbiome in female infertility and assisted conception outcomes
Description
Infertility rates are on the rise, presenting a complex array of causative factors. Recent advancements in human microbiome and associated techniques have shed light on the potential impact of vaginal microbiota disruptions on female fertility. Our study aims to investigate differences in vaginal microbiome between fertile women and those experiencing infertility. Additionally, we aim to investigate how microbial composition in infertile population may affect the success of assisted reproduction technology (ART).
OEP005207