Ziyan Wei, Institute of Microbiology, Chinese Academy of Sciences,2023.12.19

Description

Sequence data of activated sludge, inflow and effluent wastewater from wastewater treatment plant in China.

OEP004868

Jian He, Army Medical University,2023.07.19

Description

RNA-seq datasets of IVD tissues isolated from one-month-old mice. IVDs were classified into type H (hydrated) and type F (fibrotic) according to the examination of micro-MRI. Each sample/library is pooled by 4-6 IVDs.

OEP004269

Jian He, Army Medical University,2024.06.15

Description

scRNA-seq datasets of mouse discs, including two types of disc (type A and type C).

OEP005392

Ruibao Ren, Ruijin hospital affiliated to Shanghai Jiao Tong University School of Medicine,2024.05.06

Description

Acute myeloid leukemia (AML) is an aging-related malignancy, with patients aged ≥ 60 years old facing a high relapse rate and having an unfavorable prognosis after initial therapy. Umbilical cord blood (UCB) has emerged to exhibit effective anti-aging roles. Here, we conducted a perspective, phase 2, single-arm trial of UCB infusion as an adjuvant consolidation therapy in elderly AML patients (ChiCTR-OPC-15006492).Single-cell RNA sequencing (scRNA-seq) identified enhanced anti-tumor and anti-aging properties of UCB, manifested through activation of immune responses and telomere maintenance.

OEP005257

Xin Li, Shanghai Institute of Nutrition and Health,CAS,2024.01.17

Description

Previously, we characterized the whole-genomics, epigenomics, and transcriptomic profiles of prostate cancer in China. Here, we performed comprehensive proteomic and phosphoproteomic profiling of 82 paired tumor tissues and matched adjacent normal tissues from 41 Chinese patients with localized prostate cancer. We identified three proteomic subtypes with significant difference in molecular features and clinical prognosis , and found that the proteomic subtypes exhibited similar heterogeneity as the phosphoproteome. Through a biomarker null distribution analysis, we showed that the combination of proteins and phosphosites as biomarkers in prostate cancer has the best ability to predict biochemical recurrence. Then we identified a 13-protein panel that can effectively predict the biochemical recurrence, which was further validated in three independent published datasets. Finally, through integrated multi-omics analysis, we revealed the mechanistic differences underlying different proteomic subtypes, and discovered that the expression and activity of SRSF1 are essential for the malignant characteristics of prostate cancer cells. Our multi-omics data provides valuable resources for understanding the molecular mechanisms of prostate cancer in Chinese cohort, which can be used in the future to develop personalized treatment strategies, and predict prognosis for prostate cancer patients.

OEP004998

Jin Zeng, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences,2021.09.17

Description

samples in wetland of the Tibetan Plateau

OEP002737

Mukan Ji, Lanzhou University,2024.07.07

Description

This project investigates the microbial community function changes in the recently exposed glacier forefields with ecosystem succession using both metagenome and metatranscriptome

OEP005448

Hong Li, Shanghai Institute of Nutrition and Health, CAS,2024.06.28

Description

To validate CAFs can promote the proliferation and stemness of liver tumor cells, we isolated 5 CAF lines from liver cancer patients.

OEP005429

Mukan Ji, Lanzhou University,2024.07.07

Description

This project investigates the microbial community function changes in the recently exposed glacier forefields with ecosystem succession using both metagenome and metatranscriptome

OEP005447

Zheng Lab, Fudan univerisity,2023.05.04

Description

OEP004135