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  • PROJ Stool 16s rRNA sequencing of mice with thigh infection

    Lei Zhang, Shandong University,2024.02.29

    Description

    Stool 16s rRNA sequencing of mice with thigh infection

    OEP005091

  • PROJ N/A

    zhangwen xiao, ,2024.03.29

    Description

    N/A

    OEP005172

  • PROJ VLS 16S DATA in girls

    Lan Yu, zhejiang University,2024.03.26

    Description

    OEP005161

  • PROJ H3K4me3 ChIP-seq of CD4+T cell from SLE patients and HC

    Delong Feng, The Second Xiangya hospital of Central South University,2023.08.11

    Description

    OEP004403

  • PROJ ESCC_FUDAN

    Liyun Yuan, Sibs,2022.02.28

    Description

    OEP003180

  • PROJ Screening and identification of immunological signatures in cord blood of HIV-exposed uninfected infants

    Liu Yabin, Shanghai Public Health Clinical Center,2024.03.27

    Description

    In the course of immune development, HIV-exposed uninfected (HEU) infants exhibit abnormal immune function and higher infectious morbidity compared to HIV-unexposed uninfected (HUU) infants. Yet functional phenotypes and the regulators associated with in-utero HIV exposure remain largely obscure. Herein, we utilized flow cytometry and RNA-seq technologies to establish the immune and transcriptional profiling in cord blood from 9 HEU mother-infant pairs and 24 HUU pairs. On top of that, we compared the cord blood dataset with the maternal venous blood dataset to characterize the unique effects induced by in-utero HIV exposure. Flow cytometry immunophenotyping revealed a significant decrease in the level of B lymphocyte subsets in HEU cord blood compared to HUU cord blood. Expression profiling-based assessment of cell abundance indicated a marked reduction in naive B cells in HEU cord blood, supporting the altered composition of B lymphocyte subsets in HEU infants. Functional enrichment results demonstrated a propensity for suppressed innate immune responses and impaired immune regulatory function of B cells in HEU cord blood. Additionally, through a combination of differential expression analysis, co-expression network analysis, and feature selection analysis, we identified an immunologically significant HEU-related signature. This 4-gene signature could effectively assess B cell levels in cord blood, enabling discrimination between HEU and HUU infants. This study provides the first transcriptomic characterization of HEU cord blood compared to maternal venous blood and establishes a 4-gene-based classifier for predicting immunological abnormalities in HEU infants. These findings hold promise for uncovering new mechanisms underlying abnormal immune system development in infants due to in-utero HIV exposure.

    OEP005165

  • PROJ Metabolic characterization of sphere-derived prostate cancer stem cells

    Yuanyuan Luo, Dalian institute of chemical physics,2023.03.27

    Description

    Alteration of cell metabolism is one of the essential characteristics of tumor growth. Cancer stem cells (CSCs) are the initiating cells of tumorigenesis, proliferation, recurrence, and other processes, and play an important role in therapeutic resistance and metastasis. Thus, identification of the metabolic profiles in prostate cancer stem cells (PCSCs) is critical to understanding prostate cancer progression. Here, using untargeted metabolomics and lipidomics methods, we showed distinct metabolic differences between prostate cancer cells and PCSCs. We obtained DU145 spheres by ultralow-attached culture in sphere conditional medium. We use serum-induced sphere (adherent state) as control (Adh), and generation 2 (G2) and generation 3 (G3) of spheres as experimental groups to study the metabolic changes between prostate cancer cells and cancer stem cells.

    OEP004085

  • PROJ RNA-seq of photorespiratory bypass plants

    Changpeng Xin, PICB,2016.04.20

    Description

    RNA-seq of photorespiratory bypass plants

    Used ID

    NODEP00000033  

    OEP000073

  • PROJ Unveiling the Methionine Cycle: A Key Metabolic Signature and NR4A2 as a Methionine-Responsive Oncogene in Esophageal Squamous Cell Carcinoma

    wenlian Chen, Cancer institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine,2024.01.10

    Description

    RNA-seq and MeRIP-seq data

    OEP004978

  • PROJ Carotid endarterectomy ameliorates cognitive impairment via restoring cerebral hemodynamic, metabolic, and white matter status in unilateral carotid artery stenosis

    Yuting Dai, Shanghai Institute of Hematology,2024.03.23

    Description

    Carotid endarterectomy (CEA) has been widely employed to treat Carotid artery stenosis (CAS). Yet, the impact of CEA on CAS-induced cognitive impairment and underlying mechanisms remain poorly understood.

    OEP005154