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  • PROJ Altered nucleocytoplasmic export of adenosine (A)-rich circRNAs by PABPC1 contributes to neuronal function

    Li Yang, Fudan University,2024.04.27

    Description

    Circular RNAs (circRNAs) are upregulated during neurogenesis. Where and how circRNAs are localized, and what roles they play during this process have remained elusive. By comparing the nuclear and cytoplasmic circRNAs between H9 cells and H9-derived forebrain neurons (FB), we found a subset of adenosine (A)-rich circRNAs are restricted in H9 nuclei but exported to cytosols upon forebrain neuron differentiation. This differentiation-coupled circRNA subcellular relocation is modulated by the poly(A)-binding protein PABPC1. In the nucleus, newly produced (A)-rich circRNAs are bound by PABPC1 and the nuclear basket protein TPR to prevent their nucleocytoplasmic export. Modulation of (A)-rich motifs in circRNAs remarkably alters their subcellular localization. Enforced (A)-rich circRNAs in cytosols result in mRNA translation suppression. Furthermore, decreased nuclear PABPC1 upon neuronal differentiation enables the export of (A)-rich circRNAs including circRTN4(2,3), which is required for neurite outgrowth. These findings uncover subcellular localization features of circRNAs, linking their processing and function during neurogenesis.

    OEP005241

  • PROJ 20240430_WGBS

    GuLan chun, Fulgent,2024.04.29

    Description

    20240430_WGBS

    OEP005253

  • PROJ 20240429_WGBS

    GuLan chun, Fulgent,2024.04.29

    Description

    OEP005251

  • PROJ Community structure of prokaryotes in marine waters

    Li qingmei, ,2024.04.28

    Description

    These are 16S rDNA sequences predicted from metagenomic reads, used for overall analysis of the prokaryotic community structure, diversity in aquatic environments, its relationship with seawater depth, and the variation of gene relative abundance with seawater depth.

    OEP005246

  • PROJ 20240428_WGS

    GuLan chun, Fulgent,2024.04.28

    Description

    20240428_WGS

    OEP005243

  • PROJ GWAS of nail plate morphology

    MengXiang You, 上海营养与健康研究所,2024.04.21

    Description

    Summary statistics of "Genetic Loci Associated with Nail Plate Morphology in East Asian Populations"

    OEP005227

  • PROJ Data for Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases

    Yuting Dai, Shanghai Institute of Hematology,2024.04.26

    Description

    Data for Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases

    OEP005239

  • PROJ Study of MASLD-Associated Hepatocellular Carcinoma

    Tao Zeng, Guangzhou lab,2024.04.24

    Description

    Multi-omics study of p38-MAPK signaling in MASLD-Associated Hepatocellular Carcinoma and other etiologies

    OEP005235

  • PROJ N6-methyladenosine-dependent Sphingomyelin Metabolic Reprograming Promoted Immune Evasion in Pancreatic Cancer

    Rong Tang, Fudan University Shanghai Cancer Center,2024.04.23

    Description

    OEP005232

  • PROJ Untargeted LC-MS/MS analysis of DOM in Zhoushan

    Kai Tang, Xiamen University,2024.04.01

    Description

    Untargeted LC-MS/MS analysis of DOM in Zhoushan

    OEP005175