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  • PROJ Heterotrophic-autotrophic Sulfate Reduction in Three-dimensional Electrode Biofilm Reactor

    高德 壮, ,2024.04.20


    Untreated sulfate in wastewater can lead to the production of pungent hydrogen sulfide after anaerobic reduction in municipal pipes, posing a health hazard and corroding pipelines, leading to sewage leakage and further soil pollution. However, single heterotrophic sulfate reduction in sewage treatment often fails to provide satisfactory results. In contrast, three-dimensional electrode biofilm technology is effective for both heterotrophic and autotrophic reduction processes. This study aimed to treat sulfate wastewater using this technology. Different currents (R1 0 mA, R2 10 mA, R3 30 mA, and R4 50 mA) were applied to the reactor. Results showed that a 50 mA current can effectively improve sulfate reduction.


  • PROJ CS201910100905

    zhixin lu, Sinotech Genomics,2024.02.29



  • PROJ Diversity of Bacterial, fungal, and functional microbial community associated with carbon and nitrogen cyclings in freshwater littoral zones in Poyang Lake, Jiangxi province, China

    Jin Zeng, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences,2023.03.30


    Diversity of bacterial, fungal, and nirS, nirK, nosZI, nrfA, NC10, DAMO mcrA community associated with carbon and nitrogen cyclings in freshwater littoral zones in Poyang Lake, Jiangxi province, China


  • PROJ Transcriptomic assembly of Lepidodinium sp.

    Jiawei CHEN, HKUST,2023.02.28


    Clean reads from RNA-seq duplicates were trimmed using Trimmomatic v0.39 and then de-novo co-assembled using Trinity v2.14.0. Similar transcripts were clustered using CD-HIT with ‘-c 0.95’ parameter, and a single representative transcript was retained for each group. The quality of transcriptomic assembly was estimated using BUSCO v5.4.4 with the lineage dataset ‘alveolata_odb10’ (C:98.8%[S:26.3%,D:72.5%],F:0.6%,M:0.6%,n:171).


  • PROJ Metagenomic data of lakeshore wetlands in Tibetan Plateau

    Jin Zeng, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences,2023.07.27


    Rhizosphere soil, bulk soil, and sediment samples from lakeshore wetlands in Tibetan Plateau



    Zheng Lab, Fudan univerisity,2024.05.06


    Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption


  • PROJ UBE3D-mediated prostatic HSD3B1 activity deciphering tumor aggressiveness

    Xin Li, Shanghai Institute of Nutrition and Health,CAS,2023.01.03


    To distinguish aggressive prostate cancer at early disease stages is essential for personalized treatment. Here we explore the correlation of prostatic HSD3B1 activity with tumor aggressiveness to generate genomic classifiers for patient stratification and investigate mechanisms for patient metabolic heterogeneity to accelerate HSD3B1-based disease prevention and treatment. Patient prostatic HSD3B1 activity was evaluated by tracing [3H]-labeled androgen metabolism in fresh prostatic biopsies ex vivo. Potent prostatic HSD3B1 activity were more frequently found in patients with metastatic disease or worse treatment response, but less frequently found in finasteride-treated patients. Germline genetic variations and somatic mutations associated with prostatic HSD3B1 activity were evaluated. A gene signature reflecting transcriptome features of potent prostatic HSD3B1 activity was also generated as a clinic-accessible approach for patient stratification. UBE3D was found to be associated with metabolic heterogeneity, as an ubiquitin ligase regulating HSD3B1 homeostasis. Equilin was discovered as a potent HSD3B1 antagonist and inhibited tumor growth after UBE3D knockout, providing potential promising strategy for the prevention and early treatment of aggressive prostate cancer. Overall, our findings indicate that prostatic HSD3B1 activity is correlated with tumor aggressiveness at early disease stages and HSD3B1 is both a predictive biomarker but also a therapeutic target for aggressive prostate cancer.


  • PROJ lake microbiomes on the Tibetan Plateau

    Peng Xing, Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences,2023.05.16


    Structure and function of lake microbiomes on the Tibetan Plateau


  • PROJ NANOG governs cell metabolism and redox homeostasis to secure human naïve pluripotency

    Min Shao, Chinese acadmey of sciences,2024.04.09



  • PROJ Enhancer of TRPS1 rs12549956 influence hair thickness in Chinese populations

    QL Q, SINH, CAS,2024.06.06