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PROJ
Comprehensive machine learning-generated classifier identifies pro-metastatic characteristics and predicts individual treatment in pancreatic cancer: A multicenter cohort study based on super-enhancer profiling
Description
OEP004076
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PROJ
Integrative multi-Omics analysis depicts the methylome and hydroxymethylome of recurrent bladder cancers and identifies biomarkers for predicting PD-L1 expression
Description
Urinary bladder cancer (UBC) is one of the most common malignancies of the urinary tract; however, the mechanism of its high recurrence and responses to immunotherapy remains unclear, resulting in difficulties in clinical outcome prediction. Epigenetic alterations, especially DNA methylation, play important roles in bladder cancer development and are increasingly investigated as biomarkers for diagnostic or prognostic predictions. However, little is known regarding hydroxymethylation since previous studies based on bisulfite-sequencing approaches could not differentiate between 5mC and 5hmC signals, resulting in entangled methylation results. Here, we used a multi-omics approach to provide the genome, transcriptome, methylome, and hydroxymethylome landscape of both primary and recurrent bladder cancers.
OEP004094
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PROJ
XM_S_16S
Description
OEP004135
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PROJ
Microbial community structure and metabolic potential at the initial stage of soil development of the glacial forefields in Svalbard
Description
OEP003241
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PROJ
Single cell profiles of ICC with GOLP treatment
Description
Single-cell analysis deciphers the tumor microenvironment remodeling associated with response to GOLP treatment in intrahepatic cholangiocarcinoma
OEP003206
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PROJ
mangrove_project
Description
OEP001920
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PROJ
test step by step project
Description
Splicing dysregulations extensively occur in cancers, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo-YAP signaling, a key pathway that regulates cell proliferation and organ size,
OEP000774
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PROJ
Epigenetic regulation of human-specific gene expression in prefrontal cortex
Description
We collected a cohort of three humans, three chimpanzees and three macaques from PFC neurons measured by strand-specific RNA-seq technique, aiming to explore the proportion of human-specific expressed genes regulated by human-specific histone peaks, as well as to explore whether histone-modifying enzymes were contributed to epigenetic disturbance among primates.
OEP003561
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PROJ
transcriptome of Shewanella WP2
Description
Comparison of the transcriptome of WP2 and WP2ΔSP1
OEP003432
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PROJ
The recurrent spontaneous abortion (RSA) patients' abnormal decidual microenvironment
Description
The abnormal decidual microenvironment is an important cause leading to recurrent spontaneous abortion (RSA). Therefore, a comprehensive understanding of the cellular and molecular signatures of decidual cells is essential to elucidate the underlying mechanisms. Here we performed single-cell RNA sequencing on decidual non-immune and immune cells from patients with unexplained RSA and healthy donors (HDs).
OEP002901