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PROJ
Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
Description
Cancer associated fibroblasts (CAFs) have been shown to play a crucial role in regulating tumor chemotherapy and immunotherapy resistance. The therapeutic value of CAFs in prostate cancer has largely not been studied. Our research revealed that CAFs secrete CCL5, which promotes the upregulation of androgen receptor (AR) expression in prostate cancer cells, leading to resistance to enzalutamide therapy. Furthermore, CCL5 also enhances the expression of tumor programmed death-ligand 1 (PD-L1), resulting in immune escape. Mechanistically, CCL5 binds to its receptor, CC motif chemokine receptor 5 (CCR5), on prostate cancer cells and activates the AKT signaling pathway, leading to the upregulation of AR and PD-L1. The CCR5 antagonist maraviroc to inhibit the CAFs mediated CCL5 signaling pathway can effectively reduce the expression of AR and PD-L1, and improve the efficacy of enzalutamide. Together, CAFs can enhance the expression of AR and PD-L1 by paracrine CCL5 binding to CCR5 activated AKT pathway in prostate cancer, resulting in enzalutamide resistance and immune escape. And targeting CCL5-CCR5 communication as a promising treatment method to improve the effectiveness of enzalutamide.
OEP005133
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PROJ
20240320_sanger
Description
OEP005148
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PROJ
Mouse gut microbiota, colonized with human fecal samples
Description
We transplanted gut microbiota from human donors with ASD or typically developing (TD) controls into antibiotic-treated mice. We performed 16S rRNA gene sequencing on the gut microbiota of both parental and offspring mice.
OEP005037
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PROJ
Mouse brain tissue, colonized with human fecal samples
Description
We transplanted gut microbiota from human donors with ASD or typically developing (TD) controls into antibiotic-treated mice.Then, we analyzed gene expression in the brains of the mice.
OEP005038
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PROJ
Metabolomics of serum from pregnant mice (Mus musculus)
Description
Metabolomics of serum from pregnant mice (Mus musculus)
OEP005141
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PROJ
Data for Multidimensional Study of the Heterogeneity of Leukemia Cells in t(8;21) AML Identifies the Subtype with Poor Outcome
Description
Expression Data for Multidimensional Study of the Heterogeneity of Leukemia Cells in t(8;21) AML Identifies the Subtype with Poor Outcome
OEP005137
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PROJ
Untargeted LC-MS/MS analysis of DOM in East China Sea
Description
OEP004923
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PROJ
Metaproteomics of East China Sea
Description
Metaproteomics of East China Sea.
OEP004922
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PROJ
Diversity of microbial communities in Changjiang Estuary
Description
OEP004021
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PROJ
Seasonal changes and annual cycle patterns of vertical distribution characteristics and maintenance mechanism of bacterioplankton diversity in Lake Fuxian, China
Description
In this project, we conducted a comprehensive investigation into the dynamics of bacterioplankton in Lake Fuxian, a monomictic deep-water lake. The study spanned a period of six years, allowing us to capture seasonal variations in bacterioplankton community dynamics. We employed amplicon sequencing technology to analyze the microbial community composition and unravel the seasonal changes in bacterioplankton diversity and maintenance mechanisms at various depths of the lake.
OEP004643