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    Zheng Lab, Fudan univerisity,2024.05.06


    Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption


  • PROJ Prokaryotic community of urban park

    Jun Yang, Institute of Urban Environment, Chinese Academy of Sciences,2021.03.31


    Here we uesed amplicon sequencing in order to explore the habitat preference of prokaryotic community from Xiamen urban parks


  • PROJ Microeukaryotic community (18SV4) of urban park

    Jun Yang, Institute of Urban Environment, Chinese Academy of Sciences,2021.05.26


    Here we uesed amplicon sequencing in order to explore the habitat preference of microeukaryotic community from Xiamen urban parks


  • PROJ Human_islet_org_10x_scRNAseq_SWQ

    Wenqian Song, Shanghai Institutes for Biological Sciences,2024.05.15



  • PROJ Sulfurimonas-associated phages

    Ruolin Cheng, Third Institute of Oceanography, Ministry of Natural Resources, China,2024.05.16


    Sulfurimonas-associated proviruses and uncultured viral genomes (UViGs)


  • PROJ Methylparaben changes the community composition, structure and assembly processes of free-living bacteria, phytoplankton and zooplankton

    丽君 周, 中国科学院南京地理与湖泊研究所,2024.05.13


    Parabens are widely used as preservatives and bactericides in food, pharmaceuticals, and cosmetics, and are commonly found as contaminants in river and lake ecosystems. However, there are few studies on the effects of parabens on phytoplankton, zooplankton, and bacterial communities in aquatic environment.


  • PROJ Plasma metabolomics reveals the shared and distinct metabolic disturbance associated with cardiovascular events in patients with coronary artery disease

    Zheng-Jiang Zhu, Chinese Academy Of Sciences,2024.05.13


    The predictive capability of metabolic biomarkers was evaluated in the validation set. A total of 23 shared differential metabolites were associated with the composite of cardiovascular events, independent of TIMI variables, NT-proBNP and hs-cTnT. The majority were middle and long chain acylcarnitines (odds ratios ranged from 1.38 to 1.85). Distinct metabolic patterns for individual events were revealed, and glycerophospholipids alteration was specific to HF. Pathway analyses revealed tricarboxylic acid cycle played a crucial role in the development of cardiovascular events. The inclusion of metabolites into TIMI variables improved the predictive capability for the composite of cardiovascular events (AUC 0.70, 95%CI 0.64~0.75). Notably, the addition of metabolites to TIMI variables, hs-cTnT and NT-proBNP caused significant enhancement in HF risk prediction, with the AUCs of 0.91 (95%CI 0.86~0.94), 0.89 (95%CI 0.84~0.94) and 0.94 (95%CI 0.91~0.97), respectively. Acylcarnitines is the shared metabolic dysregulation in the composite of cardiovascular events, while glycerophospholipids alteration is HF specific. These findings highlight the potential utility of plasma metabolites in early and tailored risk prediction in CAD patients.


  • PROJ Fecal metagenomics of mice treated with Bifidobacterium infantis

    Ziyun Li, ,2024.05.13


    Infants with higher abundance of Bifidobacteria have fewer mobile genetic elements associated with more antimicrobial resistance (AMR) in the gut, and the effect of Bifidobacteria on the mechanisms of AMR and dissemination of AMR in the host gut flora is unknown. Here, we treated seven mice with Bifidobacterium infantis by gavage for 13 days, while eight mice were set up as a control group to observe the effects of B. infantis supplementation on the fecal metagenomics of mice.


  • PROJ The mNGS analysis of infective endocarditis

    Shiman He, Fudan university,2024.05.09


    We constructed a protein sequence database tailored to IE used for metaproteomic analyses, derived from matched metagenomes, which were generated from metagenomic next-generation sequencing (mNGS) of ten aliquots pooled and packaged from 158 vegetation samples that matched the ones used for metaproteomics in infective endocarditis.


  • PROJ ECS based on NGS in Southern Chinese couples

    Lanchun Gu, Fulgent,2024.05.10


    Comprehensive expanded carrier screening using next-generation sequencing in Southern Chinese couples