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PROJ
SNPcalling
Description
OEP004405
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PROJ
Impacts of organic materials amendment on the soil antibiotic resistome in subtropical paddy fields
Description
OEP002404
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PROJ
Warming field incubation in the Arctic
Description
OEP004357
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PROJ
Warming field incubation in the Arctic
Description
OEP004358
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PROJ
KDM6A promotes hepatocellular carcinoma progression and dictates lenvatinib efficacy by upregulating FGFR4 expression
Description
Hepatocellular carcinoma (HCC) is one of major causes of death from cancer and has a very poor prognosis with few effective therapeutic options. Despite the approval of lenvatinib for the treatment of patients with advanced HCC, only a few of patients can benefit from this targeted therapy. Our study revealed that KDM6A is significantly upregulated in HCC and is associated with a poor prognosis. Hepatic Kdm6a loss also inhibited liver tumorigenesis in a mouse liver tumor model. Mechanistically, KDM6A loss downregulated the FGFR4 expression to suppress the PI3K-AKT-mTOR signaling pathway, leading to a glucose and lipid metabolism reprogramming in HCC.
OEP004319
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PROJ
scRNA-Seq of Gli1+MuSCs/WT MuSCs
Description
To examine the distribution of Gli1-expressing cells in the skeletal muscle, we performed scRNA-seq using Gli1-CreERT2; R26-tdTomato mice, in which Gli1+ cells were labeled by tdTomato (tdT) after tamoxifen (TAM) induction. A total of 8,508 tdT+ (Gli1+) cells were sorted from hindlimb skeletal muscles of 3 adult male mice and pooled for scRNA-seq. To further confirm the expression of Gli1 in the MuSC population, CD45-CD31-Sca1-Vcam1+ MuSCs were isolated from wild-type mice by fluorescence-activated cell sorting (FACS),and analyzed by scRNA-seq. As expected, the majority of the isolated MuSCs expressed Pax7
OEP003799
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PROJ
Genomic differences among Sphingobium hydrophobicum strains with different cell surface hydrophobicity
Description
The genomes of four Sphingobium hydrophobicum strains with different cell surface hydrophobicity (CSH) were sequenced to investigate the variation responsible for CSH.
OEP004335
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PROJ
The proteogenomic landscape of diffuse large B-cell lymphoma
Description
OEP000826
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PROJ
Integrated Proteogenomic Characterization of Diffuse Large B-cell Lymphoma
Description
We performed genomic, transcriptomic, proteomic, and phosphoproteomic profilings of 124 paired diffuse large B-cell lymphoma (DLBCL) cohorts.This study provides important insight into molecular mechanisms of DLBCL, which will assist researchers in discovering novel therapeutic targets.
OEP004050
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PROJ
Characterization of Macrophage infiltration and polarization based on integrated Transcriptome analysis and histology in Primary Sjögren’s syndrome
Description
OEP004333