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  • PROJ Prokaryotic community assembly patterns in Yangtze Estuary water column

    Yihua Sun, ,2020.03.22

    Description

    We addressed the microbial composition, community assembly, and nitrogen metabolism in the oxygen minimum zones (OMZs) in Yangtze Estuary water using 16S rRNA gene sequencing, modeling, and metagenomics analyses.

    OEP000802

  • PROJ Mariana Trench sediment metagenome

    Xinxu Zhang, Shenzhen University,2022.12.08

    Description

    The sediment sample is collected from the Mariana Trench slope in the western Pacific Ocean at the water depth of 8300 mbsl.

    OEP003780

  • PROJ Mouse brain, colon and blood DNA methylation of specific target genes, colonized with human fecal samples

    Lei Zhang, Shandong University,2024.01.31

    Description

    We transplanted gut microbiota from human donors with ASD or typically developing (TD) controls into antibiotic-treated mice. We analysed DNA methylation of specific target genes of both parental and offspring mice.

    OEP005039

  • PROJ Aommonia oxidizing archaea rather than amonia oxidizing bacteria played the key role in nitrification in alkaline oligotrophic subsurface karst cave

    Hongmei Wang, China university of geosciences,2023.12.01

    Description

    OEP004782

  • PROJ Microorganisms in wetlands of the Tibetan Plateau

    Jin Zeng, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences,2021.09.17

    Description

    samples in wetland of the Tibetan Plateau

    OEP002737

  • PROJ LC-CNSm

    shenbing shan, Lingang Laboratory,2024.01.03

    Description

    Our understanding of the underlying mechanisms for central nervous system metastasis (CNSm), including leptomeningeal metastasis (LM) and brain parenchymal metastasis (BM), is limited. To address this, we conducted single-cell RNA sequencing on 24 patients with CNSm to decipher and compare the tumor microenvironment (TME) of LM and BM. Our results reveal that the TME of LM is more immunosuppressive, characterized by reduced lymphocytes and an increased presence of SPP1+ myeloid cells compared to BM. Additionally, we observed TLS-like structures in a few BM samples, associated with a favorable response to TKI therapy. Furthermore, we explored the correlation between the endothelial cell subtype Endo2 and tumor volume in BM, and systematically compared blood-brain barrier (BBB) cells in CNSm to normal conditions, revealing significant phenotypic remodeling. These findings provide insights into the clinical differences between BM and LM and contribute to a better understanding and clinical treatment of CNSm.

    OEP004944

  • PROJ Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer

    Ning Wang, Shanghai Institute of Nutrition and Health, CAS,2024.01.24

    Description

    Polyamines play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated and is considered as a therapeutic target in cancer. However, targeting polyamine metabolism as monotherapy often exhibits limited efficacy, and the underlying mechanisms are incompletely understood. Here we report that activation of polyamine catabolism promotes glutamine metabolism, leading to a targetable vulnerability in lung cancer.

    OEP005018

  • PROJ Single cell analysis of heterogeneity in acute promyelocytic leukemia

    Kankan Wang, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,2023.01.03

    Description

    Single cell analysis of heterogeneity in acute promyelocytic leukemia

    OEP003829

  • PROJ Fungal community under different moisture content in Heshang Cave

    Hongmei Wang, China university of geosciences,2022.06.15

    Description

    OEP003447

  • PROJ Bacterial community under different moisture content in Heshang Cave

    Hongmei Wang, China university of geosciences,2022.06.15

    Description

    OEP003446