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  • PROJ Cell landscape of IMQ-treated skin in the keratinocyte-specific H2Ab1-deficient mice

    Cong Peng, Central South University,2023.04.26


    Although keratinocytes have been believed to exert critical functions in the pathogenesis of psoriasis, the relationship between keratinocytes and other cell types during the development of psoriasis remains elusive. How the MHC-II molecule in the keratinocyte influences the skin environment during the pathogenesis of psoriasis remains unclear. We constructed the epidermis-specific H2-Ab1 knockout mice and H2Ab1 deficiency in the keratinocyte significantly attenuated IMQ-induced inflammatory response. We also performed single-cell RNA-sequencing on the skin tissues of H2Ab1fl/fl mice and K14.H2Ab1fl/fl mice, which revealed the keratinocyte, NK, and DC clusters were significantly reduced in the skin with keratinocyte H2Ab1 deficiency. Therefore, targeting MHC-II could be a therapeutic target for psoriasis.


  • PROJ Single cell profiles of ICC with GOLP treatment

    Guoming Shi, Zhongshan Hospital, Fudan University, Shanghai, 200032, China,2022.03.15


    Single-cell analysis deciphers the tumor microenvironment remodeling associated with response to GOLP treatment in intrahepatic cholangiocarcinoma


  • PROJ POFUT1 promotes PDL1 stability to drive immune evasion and directs liver cancer to immunotherapy

    qianyu li, shanghaijiaotong university,2023.12.05



  • PROJ Bacterial community of lake sediments in China

    Qinglong Wu, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences,2021.01.12


    IW(Inner Water)


  • PROJ ten amoeba samples

    fei liu, SUN YAT-SEN UNIVERSITY,2023.12.06


    We used metagenomic techniques to measure 10 amoeba strains, focusing on the possible health risks of endophytes present in them


  • PROJ Single-cell sequencing analysis of mouse lung tissue

    zhao ruolin, Zhejiang Chinese Medical University,2023.12.01



  • PROJ m6A-seq

    wenting Xu, Zhejiang Chinese Medical University,2023.11.29



  • PROJ 16S rRNA gene diversity during DOES incubation under different HHP

    Yu Zhang, Shanghai Jiaotong University,2023.03.13


    The microbial diversity of hadal sediment from the Mariana Trench with increasing high hydrostatic pressure (HHP; 0.1, 40, 70, 90 and 115 MPa) during incubation using the (deep ocean experimental simulator) DOES system at a flow rate of 0.3 mL/min.


  • PROJ CH0002

    Yixiang Shi, Accrete Covenant (AC) (Shanghai) Medical Technology Co., Ltd., Shanghai, China,2023.11.30



  • PROJ CF DNA methylation of blood tissue

    Wenran Li, Chinese Academy of Sciences,2023.12.02


    This study analyzed two Chinese cohorts derived from a large Chinese population study, the Shanghai CF Study, composing of individuals consecutively enrolled from Shanghai CF Community, Shanghai from June 2009 to December 2012. Samples included Han Chinese individuals who were randomly sampled from the Shanghai CF study and generated genome-wide DNA methylation profiles in the whole blood tissue. Changes in DNA methylation reflect effects of environmental changes on the human genome and may help us to explain the link between obesity and environmental factors.