Description
OEP001936
Description
OEP004415
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OEP004425
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OEP001025
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OEP004418
DescriptionHDCA supplementation ameliorated diet-induced NAFLD in C57 wild type mice. In attempt to comprehensively understand the molecular mechanism occurring during the protective effect of HDCA, transcriptomic and proteomic profiles of mouse liver were first analyzed utilizing RNA-Sequencing and Tandem Mass Tag-based quantitative proteomic approach, respectively. Then, we screened for potential HDCA binding proteins by using biotin-labeled HDCA and human proteome microarray.
OEP003800
DescriptionWe carried out a comprehensive survey of soil microbial community composition in paddy soils across China
OEP004016
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OEP004405
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OEP002404
DescriptionHepatocellular carcinoma (HCC) is one of major causes of death from cancer and has a very poor prognosis with few effective therapeutic options. Despite the approval of lenvatinib for the treatment of patients with advanced HCC, only a few of patients can benefit from this targeted therapy. Our study revealed that KDM6A is significantly upregulated in HCC and is associated with a poor prognosis. Hepatic Kdm6a loss also inhibited liver tumorigenesis in a mouse liver tumor model. Mechanistically, KDM6A loss downregulated the FGFR4 expression to suppress the PI3K-AKT-mTOR signaling pathway, leading to a glucose and lipid metabolism reprogramming in HCC.
OEP004319