DescriptionWe delved into the intrinsic cellular components and transcriptomic signatures characterizing invasive micropapillary carcinoma (IMPC).Notably, we crafted a pioneering single-cell atlas of IMPC in human breast tissue, unraveling substantial heterogeneity predominantly driven by two distinct cell subsets: epithelioid cells and interstitial cells. Pseudotime analysis unveiled unique cell trajectories for IDC-NOS cells, epithelioid IMPC cells, and interstitial IMPC cells. Of significance, we found a significant positive correlation between KRT80 expression in IMPC and clinicopathological characteristics, such as lymph node metastasis and lymphatic vessel invasion. Additionally, high KRT80 expression was associated with shorter overall survival and disease-free survival times for IMPC patients in a multicenter retrospective cohort.
OEP005223
Description
OEP004489
DescriptionThe WGS of RB cell lines
OEP005198
DescriptionThis project collected peripheral blood samples from four PCOS and four corresponding health controls. Integrated lncRNA, miRNA, and mRNA transcriptome analysis revealed key regulatory modules for polycystic ovary syndrome (PCOS).
OEP004667
DescriptionInfertility rates are on the rise, presenting a complex array of causative factors. Recent advancements in human microbiome and associated techniques have shed light on the potential impact of vaginal microbiota disruptions on female fertility. Our study aims to investigate differences in vaginal microbiome between fertile women and those experiencing infertility. Additionally, we aim to investigate how microbial composition in infertile population may affect the success of assisted reproduction technology (ART).
OEP005207
Description
OEP005180
DescriptionThe WGS of PDC with hydroxyurea of treatment
OEP005197
Description
OEP005199
DescriptionThe cohort includes 5 samples
OEP005203
DescriptionThis cohort includes 20 patients.
OEP005189