Logo

POA
Plasma Protein-based Organ Aging clocks

POA: Organ Function-Derived Protein Organ Aging Clocks for Body and Eight Organs
Protein-based Organ Aging clocks (POA) systematically fuses organ-specific functional indices with high-dimensional blood proteomic profiles to estimate organ aging. Our key innovation lies in algorithmically deconstructing organ-specific aging signals within blood proteomics, enabling the development of predictive models directly linked to organ functional decline. This approach makes the previously "invisible" process of organ aging both measurable and actionable.

When using our POA calculator, you can:

  • Upload your proteomic data
  • The system will automatically process the data (handling missing values, model retraining) and generate POA calculations for the body and eight specific organs
  • Receive POA predictions via email attachments
Upload input file
Example
Parameters of output
Note. Filling in the email address will send the result to your email address

To facilitate a comprehensive evaluation of your outcomes, we are also providing the predictive performance of POA full model as determined on the UKB dataset.

Organ Body Cardiovascular Hepatic Immune Metabolic Musculoskeletal Pulmonary Renal Brain Gray Matter White Matter FC MRI
R2 0.64 0.28 0.40 0.32 0.44 0.38 0.36 0.56 0.57 0.52 0.49 0.40
MAE 3.00 2.51 2.12 1.96 2.08 2.70 2.60 2.34 3.01 3.01 3.08 2.65
RMSE 3.80 3.28 2.75 2.51 2.73 3.40 3.34 3.04 3.82 3.79 3.93 3.30