Disorder "Heart failure"
Found 1 record
Disorder information
Disorder name:
Heart failure
Disoder ID:
Synonyms:
heart failure, Heart failure NOS, Weak heart, cardiac insufficiency, Heart failure, unspecified, failure, heart, Heart failure (disorder), insufficiency, Cardiac, Heart: [weak] or [failure NOS], Heart failure NOS (disorder), cardiac failure
Definition:
Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction
Modifier statisitcs
Record:
1
Gene:
1
Variant:
1
Reference:
1
Effect type:
Expressivity(1)
Modifier effect:
Risk factor(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| ADRB1 | ADRB1:c.1165G>C(p.Gly389Arg) | Expressivity | Risk factor | Adjusted OR=10.11; 95% CI: 2.11 to 48.53; P=0.004 | The alpha2CDel322-325 and beta1Arg389 receptors act synergistically to increase the risk of heart failure.more | more |
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