Browse by disorder


Search PhenoModifier by entering a disease or phenotype name, or select a disease or phenotype item from the list. You can get detailed information about the modifier genes as well as the sequence variants that may affect the variability of the disease or the phenotype.

Browse by Disorder

All     Disease     Phenotype     Others
1q21.1 microdeletion syndrome(5)  Disease 
Abnormal circulating tyrosine concentration(1)  Phenotype 
Abnormal Lung Morphology(4)  Phenotype 
Abnormal Renal Filtration(1)  Others 
Abnormal Thrombosis(1)  Phenotype 
Abnormality Of The Cardiovascular System(17)  Phenotype 
Abnormality Of The Liver(3)  Phenotype 
Achilles Bursitis(2)  Disease 
Acute Lymphocytic Leukemia(6)  Disease 
Acute Myeloid Leukemia(13)  Disease 
Adrenoleukodystrophy(1)  Disease 
Aganglionic Megacolon(2)  Phenotype 
Age-Related Hearing Impairment(1)  Others 
Airway Hyperresponsiveness(1)  Others 
Alagille syndrome(1)  Disease 
Allergic(1)  Others 
Alzheimer's Disease(124)  Disease 
Alzheimer's Disease 3(7)  Disease 
Amyotrophic Lateral Sclerosis(36)  Disease 
Angle-Closure Glaucoma(1)  Disease 
Arrhythmia(37)  Phenotype 
Arrhythmogenic right ventricular cardiomyopathy(1)  Disease 
Arterial Stiffness Measurement(1)  Others 
Arteriosclerosis(2)  Disease 
Arthrogryposis syndrome(3)  Disease 
Asthma(58)  Disease 
Astrocytoma(40)  Disease 
Atopic Dermatitis(1)  Disease 
Atrial Fibrillation(2)  Disease 
Attention Deficit Hyperactivity Disorder(2)  Disease 
Autism spectrum disorder(1)  Disease 
Autoimmune Hypersensitivity Disease(2)  Disease 
Autoimmune lymphoproliferative syndrome(2)  Disease 
Autosomal dominant keratitis-ichthyosis-deafness syndrome(1)  Disease 
Autosomal Dominant Polycystic Kidney Disease(11)  Disease 
Autosomal Dominant Torsion Dystonia 1(1)  Others 
Axenfeld-Rieger syndrome(1)  Disease 
Bardet-Biedl Syndrome(12)  Disease 
Behcet's Disease(5)  Disease 
Beta Thalassemia(36)  Disease 
Beta-thalassemia intermedia(1)  Disease 
Biliary Atresia(1)  Disease 
Bipolar Disorder(1)  Disease 
Bladder Benign Neoplasm(2)  Disease 
Blepharophimosis, ptosis, and epicanthus inversus syndrome(1)  Disease 
Blood Platelet Disease(4)  Disease 
Breast Cancer(310)  Disease 
Brugada Syndrome(5)  Disease 
Camurati-Engelmann disease(1)  Disease 
Cancer(11)  Disease 
Cardiomyopathy(8)  Disease 
Carotid Stenosis(1)  Disease 
Cerebral Cavernous Malformation(33)  Disease 
Cervical Cancer(13)  Disease 
Charcot-Marie-Tooth Disease(3)  Disease 
Charcot-Marie-Tooth Disease Type 1A(4)  Disease 
Chronic Kidney Disease(2)  Disease 
Chronic Obstructive Pulmonary Disease(4)  Disease 
Cirrhosis(1)  Phenotype 
Colorectal Cancer(25)  Disease 
Compensatory Emphysema(2)  Disease 
Cone-Rod Dystrophy(7)  Disease 
Congenital Bilateral Absence Of Vas Deferens(1)  Disease 
Congenital disorder of glycosylation(1)  Disease 
Congenital erythropoietic porphyria(3)  Disease 
Congenital Insensitivity To Pain With Hyperhidrosis(2)  Disease 
Congenital nephrotic syndrome(3)  Phenotype 
Congestive Heart Failure(7)  Disease 
Coronary Artery Disease(48)  Disease 
Cowden syndrome(15)  Disease 
Craniofacial Dystonia(1)  Phenotype 
Craniosynostosis(1)  Disease 
Creutzfeldt-Jakob disease(1)  Disease 
Crohn's Disease(11)  Disease 
Cystic fibrosis(271)  Disease 
Deafness(2)  Others 
Deafness With Labyrinthine Aplasia, Microtia, And Microdontia(1)  Disease 
Dent disease(2)  Disease 
Depressivity(3)  Phenotype 
Dermal Atrophy(2)  Phenotype 
Diabetes Mellitus(16)  Disease 
Diabetic Retinopathy(1)  Disease 
Diamond-Blackfan anemia(2)  Disease 
Digeorge Syndrome(2)  Disease 
Dilated Cardiomyopathy(25)  Disease 
Distal myopathy(1)  Disease 
Duchenne Muscular Dystrophy(11)  Disease 
Dystonia(1)  Disease 
Early Human Pregnancy(1)  Others 
Early-onset generalized limb-onset dystonia(1)  Disease 
Ectodermal Dysplasia(1)  Disease 
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome(1)  Disease 
Elevated Systolic Blood Pressure(1)  Phenotype 
Ellis Van Creveld syndrome(1)  Disease 
Emery-Dreifuss muscular dystrophy(5)  Disease 
Endometrial Carcinoma(2)  Disease 
Epidermolysis bullosa simplex localized type(1)  Disease 
Esophageal Basaloid Squamous Cell Carcinoma(5)  Disease 
Esophageal cancer(1)  Disease 
Facioscapulohumeral dystrophy(2)  Disease 
Facioscapulohumeral muscular dystrophy(2)  Disease 
Familial Adenomatous Polyposis(2)  Disease 
Familial amyloid polyneuropathy(2)  Disease 
Familial Combined Hyperlipidemia(22)  Disease 
Familial hypercholesterolemia(4)  Disease 
Familial Hypertrophic Cardiomyopathy(2)  Disease 
Familial Hypocalciuric Hypercalcemia(1)  Disease 
Familial long QT syndrome(2)  Disease 
Familial Mediterranean Fever(9)  Disease 
Frailty Measurement(5)  Others 
Free Sialic Acid Storage Disease(1)  Disease 
Friedreich Ataxia(1)  Disease 
Frontotemporal Dementia(8)  Disease 
Gaucher's Disease(16)  Disease 
Gaucher's Disease Type I(2)  Disease 
Generalized Seizures(1)  Phenotype 
Genetic 46,XY disorder of sex development(1)  Disease 
Glomerulonephritis(2)  Disease 
Glycogen storage disease due to muscle glycogen phosphorylase deficiency(1)  Disease 
Gorlin syndrome(7)  Disease 
Grn-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions(3)  Disease 
Gynaecopathia(16)  Others 
Head And Neck Carcinoma(2)  Disease 
Hearing Impairment(4)  Phenotype 
Hearing loss(1)  Others 
Heart conduction disease(1)  Disease 
Heart failure(1)  Others 
Hemochromatosis(5)  Disease 
Hemochromatosis Type 1(24)  Disease 
Hemoglobin H Disease(2)  Disease 
Hemophilia A(1)  Disease 
Hemophilia B(2)  Disease 
Hepatitis C(2)  Disease 
Hepatocellular Carcinoma(1)  Disease 
Hereditary Breast Cancer(4)  Disease 
Hereditary hemochromatosis type 1(1)  Disease 
Hereditary Hemorrhagic Telangiectasia(2)  Disease 
Hereditary hypophosphatemic rickets with hypercalciuria(1)  Disease 
Hereditary nonpolyposis colon cancer(4)  Disease 
Hereditary spastic paraplegia(2)  Disease 
Holoprosencephaly(3)  Disease 
Human Immunodeficiency Virus Infectious Disease(1)  Disease 
Huntington's Disease(52)  Disease 
Hyperekplexia(1)  Disease 
Hyperhomocysteinemia(1)  Disease 
Hypertension(10)  Disease 
Hypertrophic Cardiomyopathy(18)  Disease 
Hypophosphatasia(1)  Disease 
Hypospadias(1)  Disease 
Idiopathic Pulmonary Fibrosis(3)  Disease 
Infantile myofibromatosis(1)  Disease 
Inflammatory Bowel Disease(9)  Disease 
Inherited prion disease(7)  Disease 
Insulin Resistance(1)  Phenotype 
Interstitial lung disease(1)  Disease 
Interstitial Pulmonary Abnormality(1)  Phenotype 
Irritant Dermatitis(4)  Disease 
Ischemic Heart Disease(8)  Others 
Ischemic Stroke(1)  Phenotype 
Joubert syndrome(1)  Disease 
Juvenile Rheumatoid Arthritis(2)  Disease 
Kidney Disease(4)  Others 
Lafora disease(1)  Disease 
Leber Congenital Amaurosis(2)  Disease 
Leber Hereditary Optic Neuropathy(3)  Disease 
Leukemia(1)  Disease 
Liver Lipoma(1)  Disease 
Long QT Syndrome(65)  Disease 
long QT syndrome 1(3)  Disease 
Lung Adenocarcinoma(2)  Disease 
Lung Carcinoma(5)  Disease 
Lung disease(1)  Disease 
Lung Non-Small Cell Carcinoma(1)  Disease 
Lynch Syndrome(4)  Disease 
Macular Corneal Dystrophy(5)  Disease 
Marfan Syndrome(1)  Disease 
Maturity-Onset Diabetes Of The Young(1)  Disease 
Medium chain acyl-CoA dehydrogenase deficiency(1)  Disease 
Medullary thyroid carcinoma(1)  Disease 
Melanoma(34)  Disease 
Mental Deterioration(6)  Phenotype 
Metachromatic leukodystrophy(1)  Disease 
Mevalonate kinase deficiency(2)  Disease 
Migraine(3)  Disease 
Motor Neuron Disease(8)  Disease 
Moyamoya Disease(1)  Disease 
Multiple Endocrine Neoplasia Type 2A(3)  Disease 
Multiple Sclerosis(16)  Disease 
Muscular Dystrophy(5)  Disease 
Myocardial Infarction(2)  Disease 
Myopathy(6)  Disease 
Myostatin-Related Muscle Hypertrophy(1)  Disease 
Myotonic Dystrophy Type 1(3)  Disease 
Necrosis(35)  Others 
Neonatal Hyperbilirubinemia(1)  Phenotype 
Nephronophthisis(1)  Disease 
Nephropathy(2)  Phenotype 
Nephrotic Syndrome(1)  Disease 
Neural Tube Defects, Susceptibility To(5)  Disease 
Neurodegeneration(3)  Phenotype 
Neurodevelopmental Abnormality(2)  Phenotype 
Neurofibromas(2)  Phenotype 
Niemann-Pick Disease Type C(1)  Disease 
Non-Hodgkin Lymphoma(2)  Disease 
Nonalcoholic Fatty Liver Disease(120)  Disease 
Obesity(54)  Disease 
Oral Cavity Cancer(1)  Disease 
Oral Squamous Cell Carcinoma(3)  Disease 
Osteogenesis Imperfecta(1)  Disease 
Osteoporosis(3)  Disease 
Osteosarcoma(2)  Disease 
Ovarian Cancer(265)  Disease 
Pachyonychia Congenita(2)  Disease 
Pain Insensitivity(1)  Phenotype 
Pancreatic Cancer(6)  Disease 
Papillary Thyroid Carcinoma(2)  Disease 
Parkinson's disease(21)  Disease 
Parkinsonism(6)  Phenotype 
Patterned macular dystrophy(2)  Disease 
Phenylketonuria(1)  Disease 
Plasma Lipid Level(1)  Others 
Pleuritis(1)  Phenotype 
Polycystic Kidney Dysplasia(2)  Phenotype 
Polycythemia Vera(1)  Disease 
Prader-Willi syndrome(1)  Disease 
Primary coenzyme Q10 deficiency 1(2)  Disease 
Primary open angle glaucoma(4)  Disease 
Primary Progressive Multiple Sclerosis(1)  Disease 
Primary Sclerosing Cholangitis(1)  Disease 
Prion Disease(2)  Disease 
Procollagen Type I C-Terminal Peptide(3)  Others 
Progressive Familial Intrahepatic Cholestasis 3(29)  Disease 
Prostate Cancer(1)  Disease 
Pseudoexfoliation(1)  Phenotype 
Pseudoxanthoma Elasticum(25)  Disease 
Psoriasiform Dermatitis(5)  Phenotype 
Pulmonary arterial hypertension(1)  Phenotype 
Pulmonary Fibrosis(1)  Disease 
Pulmonary Hypertension(25)  Disease 
Pulmonary tuberculosis(1)  Disease 
Recessive dystrophic epidermolysis bullosa(1)  Disease 
Relapsing-Remitting Multiple Sclerosis(1)  Disease 
Renal Cell Carcinoma(2)  Disease 
Replacement of bone marrow by fibrous tissue(1)  Others 
Retinal Degeneration(1)  Disease 
Retinitis Pigmentosa(6)  Disease 
Rett Syndrome(1)  Disease 
Rheumatoid Arthritis(6)  Disease 
Sarcoma(3)  Disease 
Schizophrenia(4)  Disease 
Sclerosteosis(1)  Disease 
Scoliosis(1)  Disease 
Sepsis(39)  Phenotype 
Septic shock(1)  Others 
Severe congenital neutropenia(1)  Disease 
Short Stature Homeobox Deficiency(1)  Others 
Sickle Cell Anemia(352)  Disease 
Skeletal Muscle Atrophy(4)  Phenotype 
Smith-Lemli-Opitz Syndrome(1)  Disease 
Soft Tissue Sarcoma(1)  Phenotype 
Spinal Muscular Atrophy(4)  Disease 
Spinocerebellar ataxia type 1(3)  Disease 
Sporadic Breast Cancer(5)  Disease 
Squamous Cell Carcinoma(5)  Disease 
Stomach Cancer(2)  Disease 
Susceptibility To Human Immunodeficiency Virus Type 1(2)  Disease 
Systemic Inflammatory Response Syndrome(1)  Others 
Systemic Lupus Erythematosus(7)  Disease 
Systemic Scleroderma(2)  Disease 
Thalassemia(6)  Disease 
Thoracic Aortic Aneurysm(13)  Disease 
Thrombocytosis(1)  Disease 
Thrombotic thrombocytopenic purpura(2)  Disease 
Thyroid Cancer(1)  Disease 
Thyroid Carcinoma(4)  Disease 
Thyroid hormone resistance syndrome(1)  Disease 
Tropical Pancreatitis(3)  Disease 
Tuberous sclerosis complex(1)  Disease 
Type 1 Diabetes Mellitus(23)  Disease 
Type 2 Diabetes Mellitus(50)  Disease 
Usher syndrome type 1(4)  Disease 
Ventricular Hypertrophy(1)  Phenotype 
Von Willebrand's Disease(1)  Disease 
West syndrome(4)  Disease 
Wilson Disease(14)  Disease 
X-linked Alport syndrome(1)  Disease 
X-linked intellectual disability-retinitis pigmentosa syndrome(2)  Disease 
X-linked severe combined immunodeficiency(1)  Disease