Disorder "Hepatocellular Carcinoma"
Found 1 record
Disorder information
Disorder name:
Hepatocellular Carcinoma
Disoder ID:
OMIM entry:
Synonyms:
HCC,Hepatoma
Definition:
A kind of neoplasm of the liver that originates in hepatocytes and presents macroscopically as a soft and hemorrhagic tan mass in the liver.
Modifier statisitcs
Record:
1
Gene:
1
Variant:
1
Reference:
1
Effect type:
Expressivity(1)
Modifier effect:
Altered risk of HCC(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| PRKDC | PRKDC:c.6462+375G>T | Expressivity | Altered risk of HCC | G allele: OR=3.45, 95% CI: 2.40-4.94, T allele: OR=5.04, 95% CI: 3.28-7.76 | These individuals with the genotypes of XRCC7 rs#7003908 G alleles (namely XRCC7-TG or -GG), compared the homozygote of XRCC7 rs#7003908 T alleles (XRCC7-TT), faced increasing risk of HCC (OR, 3.45 and 5.04; 95% confidence intervals [CIs], 2.40-4.94 and 3.28-7.76, respectively)more | more |
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