Disorder "Airway Hyperresponsiveness"
Found 1 record
Disorder information
Disorder name:
Airway Hyperresponsiveness
Disoder ID:
Definition:
Airway hyperresponsiveness is the term used to describe airways that narrow too easily and too much in response to challenge with nonspecific contractile agonists. Typically, a graph of airways resistance vs. dose is sigmoid in shape; the response shows a plateau at high levels of contractile stimulus
Modifier statisitcs
Record:
1
Gene:
1
Variant:
1
Reference:
1
Effect type:
Expressivity(1)
Modifier effect:
Altered severity(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| IL4 | IL4:c.-589C>T | Expressivity | Altered severity | P<0.0001 | Polymorphism in the promoter of the IL-4 gene is associated with asthma and is a disease modifier in terms of the severity of AHR.more | more |
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