Disorder "Human Immunodeficiency Virus Infectious Disease"
Found 1 record
Disorder information
Disorder name:
Human Immunodeficiency Virus Infectious Disease 
Disoder ID:
Synonyms:
HIV infection 
Definition:
A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands. 
Modifier statisitcs
Record:
Gene:
Variant:
Reference:
Effect type:
Expressivity(1)  
Modifier effect:
Altered CD4 cell counts(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
CCR5 CCR5 Expressivity  Altered CD4 cell counts  P<0.05  Resistance to HIV-1 infection and progressionmore more
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