Disorder "Lung Carcinoma"
Found 5 records
Disorder information
Disorder name:
Lung Carcinoma
Disoder ID:
Definition:
A malignant neoplasm involving the lung.
Modifier statisitcs
Record:
5
Gene:
3
Variant:
5
Reference:
3
Effect type:
Expressivity(5)
Modifier effect:
Risk factor(4)
,Altered life span(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| XRCC1 | XRCC1:c.1196A>G(p.Gln399Arg) | Expressivity | Risk factor | OR=5.91; 95% CI: 2.09-16.72 | The XRCC1 Arg399Gln polymorphism may serve as a risk modifiermore | more |
| mtDNA | mtDNA:c.16298T/C | Expressivity | Risk factor | P=0.047 | The minor allele of nucleotide 16298T/C was specifically associated with the risk of small cell lung cancermore | more |
| mtDNA:c.235A/G | Expressivity | Risk factor | P=0.001 | The minor alleles of nucleotides 235A/G and 324A/G were associated with an increased risk for lung cancer patientsmore | more | |
| mtDNA:c.324A/G | Expressivity | Risk factor | P=0.007 | The minor alleles of nucleotides 235A/G and 324A/G were associated with an increased risk for lung cancer patientsmore | more | |
| IGF1 | IGF1:c.*6433G>C | Expressivity | Altered life span | HR=0.58; 95% CI: 0.40-0.85; p for heterogeneity test = 0.045 | rs5742714 in IGF1 may be a genetic modifier for NSCLC prognosis in this Chinese populationmore | more |
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