Disorder "Motor Neuron Disease"
Found 8 records
Disorder information
Disorder name:
Motor Neuron Disease
Disoder ID:
Definition:
A neurodegenerative disease that is located_in the motor neurones.
Modifier statisitcs
Record:
8
Gene:
8
Variant:
8
Reference:
1
Effect type:
Expressivity(8)
Modifier effect:
Altered survival time(4)
,Altered onset time(3)
,Risk factor(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| UNC13A | UNC13A:c.2473-324T>G | Expressivity | Altered survival time | P=0.003 | Significantly associated with survival after onsetmore | more |
| UBAP1 | UBAP1:rs7018487 | Expressivity | Altered onset time | P=0.003 | Significantly associated with age at onsetmore | more |
| PRNP | PRNP:rs6052771 | Expressivity | Altered onset time | P=0.003 | Significantly associated with age at onsetmore | more |
| MT1E | MT1E:rs7403881 | Expressivity | Altered onset time | P=0.001 | Significantly associated with age at onsetmore | more |
| GRN | GRN:rs5848 | Expressivity | Altered survival time | P=0.001 | Significantly associated with survival after onsetmore | more |
| ELP3 | ELP3:rs13268953 | Expressivity | Altered survival time | P=0.003 | Significantly associated with survival after onsetmore | more |
| C9orf72 | ALAD:rs1800435 | Expressivity | Risk factor | P=0.003 | Significantly associated with motor neuron diseasemore | more |
| APOE | APOE | Expressivity | Altered survival time | P=0.004 | Significantly associated with survival after onsetmore | more |
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