Disorder "Arrhythmia"
Found 37 records
Disorder information
Disorder name:
Arrhythmia
Disoder ID:
Definition:
Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both.
Modifier statisitcs
Record:
37
Gene:
15
Variant:
34
Reference:
3
Effect type:
Expressivity(37)
Modifier effect:
Risk factor(28)
,Altered severity(6)
,Altered current amplitude(2)
,Altered ectopic trigger and maintenance of AF(1)
Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
---|---|---|---|---|---|---|
SERPINE1 | SERPINE1:c.5G>4G | Expressivity | Risk factor | From review article | This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more | more |
SCN5A | SCN5A:c.100C>T(p.Arg34Cys) | Expressivity | Risk factor | From review article | This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more | more |
SCN5A:c.1535C>T(p.Thr512Ile) | Expressivity | Altered severity | From review article | SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more | more | |
SCN5A:c.3269C>T(p.Pro1090Leu) | Expressivity | Risk factor | From review article | This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more | more | |
SCN5A:c.3308C>A(p.Ser1103Tyr) | Expressivity | Altered severity | From review article | SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more | more | |
SCN5A:c.3823G>A(p.Asp1275Asn) | Expressivity | Altered severity | From review article | SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more | more | |
SCN5A:c.5296A>T(p.Met1766Leu) | Expressivity | Altered severity | From review article | SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more | more | |
SCN5A:c.5851G>T(p.Val1951Leu) | Expressivity | Risk factor | From review article | This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more | more | |
SCN5A:c.845G>A(p.Arg282His) | Expressivity | Altered severity | From review article | SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more | more | |
SCN5A:c.1673A>G(p.His558Arg) | Expressivity | Risk factor | From review article | This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more | more |