Disorder "Arrhythmia"
Found 37 records
Disorder information
Disorder name:
Arrhythmia 
Disoder ID:
Definition:
Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both. 
Modifier statisitcs
Record:
37 
Gene:
15 
Variant:
34 
Reference:
Effect type:
Expressivity(37)  
Modifier effect:
Risk factor(28) ,Altered severity(6) ,Altered current amplitude(2) ,Altered ectopic trigger and maintenance of AF(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
SERPINE1 SERPINE1:c.5G>4G Expressivity  Risk factor  From review article  This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more more
SCN5A SCN5A:c.100C>T(p.Arg34Cys) Expressivity  Risk factor  From review article  This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more more
SCN5A:c.1535C>T(p.Thr512Ile) Expressivity  Altered severity  From review article  SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more more
SCN5A:c.3269C>T(p.Pro1090Leu) Expressivity  Risk factor  From review article  This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more more
SCN5A:c.3308C>A(p.Ser1103Tyr) Expressivity  Altered severity  From review article  SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more more
SCN5A:c.3823G>A(p.Asp1275Asn) Expressivity  Altered severity  From review article  SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more more
SCN5A:c.5296A>T(p.Met1766Leu) Expressivity  Altered severity  From review article  SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more more
SCN5A:c.5851G>T(p.Val1951Leu) Expressivity  Risk factor  From review article  This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more more
SCN5A:c.845G>A(p.Arg282His) Expressivity  Altered severity  From review article  SCN5A may also account for more severe phenotypic manifestations in conduction disease31 and Brugada syndrome,may exacerbate or alleviate the severity of the disease.more more
SCN5A:c.1673A>G(p.His558Arg) Expressivity  Risk factor  From review article  This genetic variance may contribute as a second genetic modifier for arrhythmia development is under current investigation.more more
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